ZFYVE27 and OTOP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZFYVE27	OTOP3
Description		zinc finger FYVE-type containing 27	otopetrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Membrane Axon Dendrite Growth Cone Membrane Cell Projection Recycling Endosome Membrane Endoplasmic Reticulum Tubular Network	Plasma Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Protein Binding Proton Channel Activity Identical Protein Binding
	Biological Process	Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Axon Extension Neurotrophin TRK Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Formation Protein Localization To Plasma Membrane	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Proton Transmembrane Transport
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Iron status biomarkers (ferritin levels) ( 33536631)
Interacting Genes		18 interacting genes: APP GIMAP1 GIMAP5 IER3IP1 ORMDL1 OTOP3 PIP4P2 SACM1L SEC22A SLC30A8 SLC66A2 STX7 TMEM128 TMEM14C TMEM243 TMEM65 TSPAN2 YIF1A	8 interacting genes: COMT EBP FAM210B SLC10A1 SLC13A4 TMEM237 TMEM31 ZFYVE27
Entrez ID		118813	347741
HPRD ID		15735	09700
Ensembl ID		ENSG00000155256	ENSG00000182938
Uniprot IDs		A0A0S2Z5V0 A0A0S2Z627 B7Z6J9 Q5T4F4	Q7RTS5
PDB IDs		1X4U
Enriched GO Terms of Interacting Partners?		Membrane Microglia Development Intracellular Transport Vesicle-mediated Transport Insulin Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Dephosphorylation Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell SNAP Receptor Activity Golgi Membrane Endoplasmic Reticulum Membrane COPII-coated ER To Golgi Transport Vesicle Phospholipid Dephosphorylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Endosome Amylin Binding Positive Regulation Of Toll Signaling Pathway	Cellular Response To Phosphate Starvation Norepinephrine Secretion Catechol O-methyltransferase Activity Membrane Symporter Activity C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Cholestenol Delta-isomerase Activity Sodium:sulfate Symporter Activity Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity O-methyltransferase Activity Dopamine Secretion Renal Protein Absorption Catecholamine Catabolic Process Norepinephrine Transport Nonassociative Learning Response To Dopamine Dopamine Catabolic Process Organic Hydroxy Compound Transport Catecholamine Secretion Cerebellar Cortex Morphogenesis Bile Acid Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Sodium Ion Transport Ossification Involved In Bone Maturation Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment Endoplasmic Reticulum Tubular Network Formation Growth Cone Membrane Renal Tubular Secretion Cellular Response To Cocaine
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