CLSTN1 and KLC1

Number of citations of the paper that reports this interaction (PubMedID 17332754)
32

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CLSTN1	KLC1
Description		calsyntenin 1	kinesin light chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Postsynaptic Density Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Endosome Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Kinesin Binding X11-like Protein Binding	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	Regulation Of Cell Growth Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Synapse Maturation Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways			MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		14 interacting genes: APBA2 APBB1 BAHCC1 COL17A1 KIF2A KLC1 KLC2 MCM3AP MDM2 PRNP SETDB1 SLK TOPBP1 TRIP12	29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		22883	3831
HPRD ID		10837	02489
Ensembl ID		ENSG00000171603	ENSG00000126214
Uniprot IDs		B4E3Q1 O94985	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs			3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Kinesin Complex Amyloid-beta Binding Heterochromatin Organization Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Chromatin Organization Chromatin Binding Cytoskeletal Motor Activity Kinesin Binding Response To Formaldehyde Cellular Response To Vitamin B1 Type 8 Metabotropic Glutamate Receptor Binding Kinesin I Complex Regulation Of Protein Processing Protein Destabilization Regulation Of Protein Maturation	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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