MORC2 and SENP1

Number of citations of the paper that reports this interaction (PubMedID 36793866)
78

Data Source:
BioGRID (enzymatic study)

		MORC2	SENP1
Description		MORC family CW-type zinc finger 2	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Chromatin Binding Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process DNA Damage Response Constitutive Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation	Proteolysis Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Primary Metabolic Process Regulation Of Postsynapse Assembly
Pathways		Fatty acyl-CoA biosynthesis Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	SUMO is proteolytically processed RHOF GTPase cycle
Drugs
Diseases
GWAS			Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		6 interacting genes: CEBPA PARP1 SENP1 SIRT2 TRIM28 UBC	26 interacting genes: APP CAV3 EIF5A GCM1 HDAC1 HIPK1 HIPK2 KCNK1 MORC2 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28 USP7
Entrez ID		22880	29843
HPRD ID		11699	07153
Ensembl ID		ENSG00000133422	ENSG00000079387
Uniprot IDs		Q9Y6X9	Q9P0U3
PDB IDs		5OF9 5OFA 5OFB	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Histone Deacetylase Binding Proteolysis Chromatin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription NAD Binding Positive Regulation Of RNA Metabolic Process Macrophage Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Heterochromatin Constitutive Heterochromatin Formation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Regulation Of Transcription By RNA Polymerase II NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Macromolecule Metabolic Process Defense Response Positive Regulation Of Myofibroblast Differentiation	Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Protein Modification Process Post-translational Protein Modification Protein Metabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Protein Tag Activity Protein-containing Complex Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intracellular Transport Cellular Response To Stress Cytoplasmic Periphery Of The Nuclear Pore Complex DNA Damage Response Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nuclear Body Organization Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization Deubiquitinase Activity Maintenance Of Protein Location In Nucleus Ubiquitin-like Protein Ligase Binding Nuclear Pore Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Postsynaptic Cytosol Negative Regulation Of Transcription By RNA Polymerase II SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments
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