MORC2

Description		MORC family CW-type zinc finger 2
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Chromatin Binding Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process DNA Damage Response Constitutive Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation
Pathways		Fatty acyl-CoA biosynthesis Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS
Interacting Genes		6 interacting genes: CEBPA PARP1 SENP1 SIRT2 TRIM28 UBC
Entrez ID		22880
HPRD ID		11699
Ensembl ID		ENSG00000133422
Uniprot IDs		Q9Y6X9
PDB IDs		5OF9 5OFA 5OFB
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Histone Deacetylase Binding Proteolysis Chromatin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription NAD Binding Positive Regulation Of RNA Metabolic Process Macrophage Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Heterochromatin Constitutive Heterochromatin Formation Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Regulation Of Transcription By RNA Polymerase II NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Macromolecule Metabolic Process Defense Response Positive Regulation Of Myofibroblast Differentiation
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