RAB25 and MYO5B

Number of citations of the paper that reports this interaction (PubMedID 11408590)
51

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RAB25	MYO5B
Description		RAB25, member RAS oncogene family	myosin VB
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Cell Projection Recycling Endosome Extracellular Exosome	Cytoplasm Actin Cytoskeleton Membrane Myosin Complex Cytoplasmic Vesicle Membrane Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding
	Biological Process	Epithelial Cell Morphogenesis Exocytosis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Migration Protein Transport Pseudopodium Organization Regulation Of Vesicle-mediated Transport	Renal Water Homeostasis Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport
Pathways		RAB geranylgeranylation	Vasopressin regulates renal water homeostasis via Aquaporins
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Parkinson's disease ( 32201043)	Apolipoprotein A1 levels ( 29084231 32203549) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Longevity (100 years and older) ( 33948810) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		14 interacting genes: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SMAD4 SMURF2 TGFBR1	23 interacting genes: AMOTL2 ATOSB BNIP2 COIL CXCR2 EFHC2 FXR1 GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SHANK3 SMAD3 SMARCA2 TCF4 TRIM3 TRIM54 ZNHIT1
Entrez ID		57111	4645
HPRD ID		06698	07582
Ensembl ID		ENSG00000132698	ENSG00000167306
Uniprot IDs		P57735	Q7Z7A5 Q9ULV0
PDB IDs		2OIL 3TSO	4J5M 4LNZ 4LWZ 4LX0
Enriched GO Terms of Interacting Partners?		SMAD Binding Recycling Endosome Negative Regulation Of Adiponectin Secretion Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Endosome Recycling Endosome Membrane Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Small GTPase Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Pattern Specification Process BMP Receptor Activity Positive Regulation Of Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Vesicle-mediated Transport Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Negative Regulation Of Protein Secretion Activin Binding BMP Signaling Pathway In Utero Embryonic Development Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chordate Embryonic Development Regulation Of Hormone Secretion Regulation Of Hormone Levels Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Cellular Response To Growth Factor Stimulus I-SMAD Binding Gastrulation With Mouth Forming Second Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulated Exocytosis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling	Myosin V Binding Regulation Of Long-term Neuronal Synaptic Plasticity Recycling Endosome Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Germ Cell Development G Protein Activity Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cell Projection Exocytosis Transcytosis Regulation Of Endocytic Recycling Recycling Endosome Membrane Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Amyloid-beta Clearance Epithelial Cell Morphogenesis
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