RAB25 and RAB11FIP1

Number of citations of the paper that reports this interaction (PubMedID 37232246)
61

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		RAB25	RAB11FIP1
Description		RAB25, member RAS oncogene family	RAB11 family interacting protein 1
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Cell Projection Recycling Endosome Extracellular Exosome	Cytoplasm Endosome Cytosol Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding	Protein Binding Small GTPase Binding
	Biological Process	Epithelial Cell Morphogenesis Exocytosis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Migration Protein Transport Pseudopodium Organization Regulation Of Vesicle-mediated Transport	Protein Transport Regulated Exocytosis Negative Regulation Of Adiponectin Secretion
Pathways		RAB geranylgeranylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Parkinson's disease ( 32201043)	Axial length ( 24144296)
Interacting Genes		14 interacting genes: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SMAD4 SMURF2 TGFBR1	6 interacting genes: RAB11A RAB25 RAB4A RFFL SNCA TRIM21
Entrez ID		57111	80223
HPRD ID		06698	09787
Ensembl ID		ENSG00000132698	ENSG00000156675
Uniprot IDs		P57735	Q6WKZ4
PDB IDs		2OIL 3TSO	4D0G
Enriched GO Terms of Interacting Partners?		SMAD Binding Recycling Endosome Negative Regulation Of Adiponectin Secretion Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Endosome Recycling Endosome Membrane Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Small GTPase Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Pattern Specification Process BMP Receptor Activity Positive Regulation Of Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Vesicle-mediated Transport Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Negative Regulation Of Protein Secretion Activin Binding BMP Signaling Pathway In Utero Embryonic Development Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chordate Embryonic Development Regulation Of Hormone Secretion Regulation Of Hormone Levels Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Cellular Response To Growth Factor Stimulus I-SMAD Binding Gastrulation With Mouth Forming Second Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulated Exocytosis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling	Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial Cell Migration G Protein Activity Vesicle-mediated Transport In Synapse Recycling Endosome Membrane Regulation Of Locomotion Recycling Endosome Myosin V Binding Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Exocytosis Receptor Localization To Synapse Cytoplasmic Vesicle Regulation Of Cell Motility Regulation Of Cell Migration GTPase Activity GTP Binding Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Destabilization Secretion By Cell Synaptic Vesicle Endosomal Processing Pseudopodium Membrane Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Vesicle-mediated Transport Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Response To Type II Interferon Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Pseudopodium Organization Secretion Establishment Of Protein Localization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Activin Receptor Activity, Type II Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Protein Localization To Cleavage Furrow
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