RAB25 and RAB11FIP3

Number of citations of the paper that reports this interaction (PMID 11495908)
79

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro, two hybrid)

		RAB25	RAB11FIP3
Gene Name		RAB25, member RAS oncogene family	RAB11 family interacting protein 3 (class II)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic Membrane-bounded Vesicle Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Recycling Endosome Extracellular Vesicular Exosome	Nucleoplasm Endosome Centrosome Microtubule Organizing Center Cytosol Midbody Cleavage Furrow Intracellular Membrane-bounded Organelle Intercellular Bridge Recycling Endosome Recycling Endosome Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding	Calcium Ion Binding Protein Binding Rab GTPase Binding ADP-ribosylation Factor Binding Protein Homodimerization Activity
	Biological Process	Epithelial Cell Morphogenesis Intracellular Protein Transport Exocytosis Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial Cell Migration Pseudopodium Organization Melanosome Transport Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport	Cytokinesis Organelle Organization Vesicle-mediated Transport Endocytic Recycling
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SMAD4 SMURF2 TGFBR1	9 interactors: ARF4 ARF5 ARF6 IKBKG RAB11A RAB11B RAB11FIP4 RAB25 TOMM34
Entrez ID		57111	9727
HPRD ID		06698	18521
Ensembl ID		ENSG00000132698	ENSG00000090565
Uniprot IDs		P57735	O75154
PDB IDs		2OIL 3TSO	2D7C 2HV8
Enriched GO Terms of Interacting Partners?		Response To Transforming Growth Factor Beta BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulated Secretory Pathway Endocardial Cell Differentiation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Endothelial Cell Activation Response To Growth Factor Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Germ Cell Migration Negative Regulation Of Cell Proliferation Cellular Response To Organic Substance Regulation Of SMAD Protein Import Into Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Mesenchymal Cell Development Endocardium Development Atrioventricular Valve Morphogenesis Pharyngeal System Development Cardiocyte Differentiation Mesenchymal Cell Differentiation Atrioventricular Valve Development Protein Transport Mesoderm Development Vesicle-mediated Transport Establishment Of Protein Localization Cardiac Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Pattern Specification Process Activin Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Ameboidal-type Cell Migration Cellular Localization Renal Water Homeostasis In Utero Embryonic Development Heart Development Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Heart Valve Morphogenesis Response To Organic Substance Heart Valve Development Cell Cycle Process Mesenchyme Development	Small GTPase Mediated Signal Transduction Protein Transport Establishment Of Protein Localization Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Intracellular Signal Transduction Establishment Of Vesicle Localization Protein Localization Vesicle Localization Cellular Pigmentation Rab Protein Signal Transduction Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Pigmentation Organelle Localization Transport Cellular Protein Localization Ras Protein Signal Transduction Cellular Localization Exocytosis Intracellular Protein Transport Multivesicular Body Assembly Regulation Of Multivesicular Body Size Establishment Of Localization In Cell Positive Regulation Of Epithelial Cell Migration Cell Division Signal Transduction Cytokinesis Secretion By Cell Protein Localization To Organelle Constitutive Secretory Pathway Multivesicular Body Organization Signaling Cell Communication Pseudopodium Organization Regulation Of Endosome Size Regulation Of Epithelial Cell Migration Secretion Exosomal Secretion Intracellular Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Stimulus Regulation Of Protein Localization Endosomal Transport Myeloid Cell Apoptotic Process Cellular Response To Acidic PH Plasma Membrane To Endosome Transport
Tagcloud ?		acini acquire alpha5beta1 basement cargo clic3 com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts recycling trafficking transferred
Tagcloud (Difference) ?		acini acquire alpha5beta1 basement cargo clic3 com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts recycling trafficking transferred
Tagcloud (Intersection) ?