RAB25 and ACVR1

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		RAB25	ACVR1
Gene Name		RAB25, member RAS oncogene family	activin A receptor, type I
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic Membrane-bounded Vesicle Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Recycling Endosome Extracellular Vesicular Exosome	Integral Component Of Plasma Membrane Apical Part Of Cell Activin Receptor Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Epithelial Cell Morphogenesis Intracellular Protein Transport Exocytosis Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial Cell Migration Pseudopodium Organization Melanosome Transport Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport	G1/S Transition Of Mitotic Cell Cycle Patterning Of Blood Vessels Urogenital System Development In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Mitral Valve Morphogenesis Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs			Adenosine triphosphate 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SMAD4 SMURF2 TGFBR1	64 interactors: AP2B1 BAMBI BMP2 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FCHO1 FGD6 FKBP4 FNTA GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		57111	90
HPRD ID		06698	00021
Ensembl ID		ENSG00000132698	ENSG00000115170
Uniprot IDs		P57735	D3DPA4 Q04771
PDB IDs		2OIL 3TSO	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
Enriched GO Terms of Interacting Partners?		Response To Transforming Growth Factor Beta BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulated Secretory Pathway Endocardial Cell Differentiation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Endothelial Cell Activation Response To Growth Factor Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Germ Cell Migration Negative Regulation Of Cell Proliferation Cellular Response To Organic Substance Regulation Of SMAD Protein Import Into Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Mesenchymal Cell Development Endocardium Development Atrioventricular Valve Morphogenesis Pharyngeal System Development Cardiocyte Differentiation Mesenchymal Cell Differentiation Atrioventricular Valve Development Protein Transport Mesoderm Development Vesicle-mediated Transport Establishment Of Protein Localization Cardiac Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Pattern Specification Process Activin Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Ameboidal-type Cell Migration Cellular Localization Renal Water Homeostasis In Utero Embryonic Development Heart Development Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Heart Valve Morphogenesis Response To Organic Substance Heart Valve Development Cell Cycle Process Mesenchyme Development	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Intracellular Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Metabolic Process Response To Stimulus BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cell Differentiation Regulation Of Cellular Process Ras Protein Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Skeletal System Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Response To Organic Substance Positive Regulation Of Gene Expression Epithelium Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation
Tagcloud ?		acini acquire alpha5beta1 basement cargo clic3 com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts recycling trafficking transferred	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Difference) ?		acini acquire alpha5beta1 basement cargo clic3 com compartments concert correspondingly drives endosomal endosomes integrin invasiveness matrigel mcf10dcis metalloproteinase mmp mmp14 mt1 opposes organotypic plane plugs predicts recycling trafficking transferred	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Intersection) ?