KRTAP3-1 and ADAM12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP3-1	ADAM12
Description		keratin associated protein 3-1	ADAM metallopeptidase domain 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Extracellular Region Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process		Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis
Pathways		Keratinization	Signaling by EGFR Invadopodia formation
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 26184070) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		83 interacting genes: ADAM12 AGXT ANAPC11 BMP7 CDKN1A CELA2B CERK CFP CIMIP1 CNNM3 CREB5 CTRC CYSRT1 DMRT3 DOCK2 FAM168A FAM222B FOXH1 FRS3 GATA2 GNE GPS2 GSTP1 HCK HEY2 HOXB9 HR HSF4 IL16 ITGB4 KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP9-3 KRTAP9-8 LCE1B LCE2B LCE3A LCE3D LCE4A LCE5A LMO4 LRRC41 MAPKBP1 MRPL40 MYPOP NOTCH2NLA NTAQ1 OTX1 PATZ1 PCSK5 PHLDA1 PKIB PLSCR4 POLR1C PTPMT1 PVR RBPMS RECK REEP6 RNF44 SAMD7 SAXO4 SLC5A5 SMARCC1 SPAG8 SPMIP9 TEKT3 TLX3 TNS2 VASN VENTX VGLL3 WDR25 YPEL3 ZFHX2 ZNF414 ZNF446	40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1
Entrez ID		83896	8038
HPRD ID		13937	04092
Ensembl ID		ENSG00000212901	ENSG00000148848
Uniprot IDs		Q9BYR8	A8K6G4 O43184 Q5JRP2
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratinization Keratin Filament Epidermis Development Axonemal A Tubule Inner Sheath Tissue Development Ventral Spinal Cord Interneuron Differentiation Heart Trabecula Morphogenesis Cellular Response To Cell-matrix Adhesion	Intermediate Filament Keratin Filament Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Developmental Process Fibronectin Binding Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Phosphotyrosine Residue Binding T Cell Costimulation Insulin-like Growth Factor II Binding Protein Binding Cytosol Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Substrate Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Epidermis Development Hair Cycle Negative Regulation Of Cell-substrate Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Keratinization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of MAPK Cascade Angiotensin-activated Signaling Pathway Actin Filament Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
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