FKBP1B and TRIM69

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		FKBP1B	TRIM69
Description		FKBP prolyl isomerase 1B	tripartite motif containing 69
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GO Annotations	Cellular Component	Cytoplasm Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Calcium Channel Regulator Activity Protein Binding FK506 Binding Isomerase Activity Calcium Channel Inhibitor Activity Transmembrane Transporter Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Heart Rate Protein Folding 'de Novo' Protein Folding Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Glucose Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neuronal Action Potential Propagation Calcium-mediated Signaling Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Refolding T Cell Proliferation Negative Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Protein Maturation Response To Redox State Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome
Pathways		Stimuli-sensing channels Ion homeostasis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronotype ( 27494321) Quantitative traits ( 19197348)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		12 interacting genes: ADAMTSL4 BMPR1A CAMK2D GMCL1 KRT31 KRT40 KRTAP1-1 REL RYR2 RYR3 TGFBR1 TRIM69	55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		2281	140691
HPRD ID		02795	11518
Ensembl ID		ENSG00000119782	ENSG00000185880
Uniprot IDs		F8W6G9 P68106	H0YL66 Q86WT6
PDB IDs		1C9H 4C02 4IQ2 4IQC 5HKG 5L1D 5T15 5T9M 5T9N 5T9R 5T9S 5T9V 5TA3 5TAL 5TAM 5TAN 5TAP 5TAQ 5TAS 5TAT 5TAU 5TAV 5TAW 5TAX 5TAY 5TAZ 5TB0 5TB1 5TB2 5TB3 5TB4 6JGZ 6JH6 6JHN 6JI0 6JI8 6JII 6JIU 6JIY 6JRR 6JRS 6M2W 6PV6 6W1N 6WOT 6WOU 6WOV 6X32 6X33 6X34 6X35 6X36 7CF9 7JMF 7JMG 7JMH 7JMI 7JMJ 7M6A 7M6L 7T64 7T65 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 7VML 7VMM 7VMN 7VMO 7VMP 7VMQ 7VMR 7VMS 8DTY 8DTZ 8DUJ 8DVE 8DVV 8SEN 8SEO 8SEP 8SEQ 8SER 8SES 8SET 8UQ2 8UQ3 8UQ4 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM 8XJI 8XKH 8XLF 8XLH 8Y40 9C1E 9C1F 9CGP 9CGQ	4NQJ 6YXE
Enriched GO Terms of Interacting Partners?		Ventricular Cardiac Muscle Tissue Morphogenesis Tissue Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type I Sarcoplasmic Reticulum Membrane Calcium-induced Calcium Release Activity Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Ventricular Compact Myocardium Morphogenesis Sarcoplasmic Reticulum Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Caffeine Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Transmembrane Receptor Protein Serine/threonine Kinase Activity Cellular Response To Purine-containing Compound Keratin Filament Ventricular Trabecula Myocardium Morphogenesis Sarcoplasmic Reticulum Calcium Ion Transport Response To Caffeine Sarcolemma Smooth Endoplasmic Reticulum Heart Trabecula Morphogenesis Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of The Force Of Heart Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Intermediate Filament Regulation Of Cardiac Muscle Cell Action Potential Calcium-mediated Signaling Monoatomic Cation Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calmodulin Binding Cellular Response To Alkaloid Ventricular Septum Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Intracellular Chemical Homeostasis Positive Regulation Of SMAD Protein Signal Transduction Calcium Ion Homeostasis SMAD Binding Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Neural Crest Cell Differentiation Neural Plate Mediolateral Regionalization	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization
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