FKBP1B and CAMK2D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FKBP1B	CAMK2D
Gene Name		FK506 binding protein 1B, 12.6 kDa	calcium/calmodulin-dependent protein kinase II delta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Receptor Binding Ryanodine-sensitive Calcium-release Channel Activity Protein Binding FK506 Binding Calcium Channel Inhibitor Activity Cyclic Nucleotide Binding Ion Channel Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Inhibitor Activity Titin Binding Protein Homodimerization Activity Ion Channel Binding Nitric-oxide Synthase Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization 'de Novo' Protein Folding Smooth Muscle Contraction Response To Glucose Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Neuronal Action Potential Propagation Protein Maturation By Protein Folding Insulin Secretion Negative Regulation Of Protein Phosphatase Type 2B Activity Response To Vitamin E Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Protein Refolding T Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Axon Regeneration Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Chaperone-mediated Protein Folding Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Calcium Ion Transmembrane Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Regulation Of Cell Growth Response To Hypoxia Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Synaptic Transmission Regulation Of Heart Contraction Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Potassium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Heat Positive Regulation Of Rac Protein Signal Transduction Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Oligomerization Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Localization Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cellular Response To Heat Regulation Of Histone Deacetylase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Ion channel transport Stimuli-sensing channels	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Quantitative traits ( 19197348)	White matter integrity (interaction) ( 23218918)
Protein-Protein Interactions		9 interactors: ADAMTSL4 BMPR1A CAMK2D GMCL1 KRT31 KRT40 REL RYR2 TRIM69	27 interactors: ACTN2 ARL2BP BANP CAMK2B CD5 CREM DNAL4 EPHA10 FAM171B FKBP1B FNDC3B FXR2 GRIN2B HDAC4 HNMT IFNGR2 MOAP1 MRPL11 RPS18 RPS4X SPATA24 SRPK1 STAT1 TNPO2 TTC5 VIM WASF3
Entrez ID		2281	817
HPRD ID		02795	09653
Ensembl ID		ENSG00000119782	ENSG00000145349
Uniprot IDs		P68106	D6R938 E9PF82 Q13557
PDB IDs		1C9H 4C02	2VN9 2W2C 2WEL 3GP2
Enriched GO Terms of Interacting Partners?		Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Muscle Hypertrophy Regulation Of The Force Of Heart Contraction Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Heart Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Neural Plate Mediolateral Regionalization Left Ventricular Cardiac Muscle Tissue Morphogenesis Paraxial Mesoderm Structural Organization Positive Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Regulation Of Striated Muscle Contraction Calcium-mediated Signaling Heart Development Positive Regulation Of Sequestering Of Calcium Ion Type B Pancreatic Cell Apoptotic Process Response To Calcium Ion Second-messenger-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Cardiac Muscle Cell Contraction Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Ion Homeostasis Regulation Of Generation Of L-type Calcium Current Mesendoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Positive Regulation Of The Force Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Heart Contraction Tissue Development Positive Regulation Of Rac Protein Signal Transduction	Signaling Cell Communication Muscle System Process Protein Localization To Organelle Signal Transduction Viral Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cell Differentiation Interferon-gamma-mediated Signaling Pathway Multicellular Organismal Development Response To Stress Developmental Process Regulation Of Cellular Process Translational Termination Cellular Response To Interferon-gamma Actin-myosin Filament Sliding Muscle Filament Sliding Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Response To Cytokine Response To Interferon-gamma Translational Elongation Negative Regulation Of Transporter Activity Cellular Protein Complex Disassembly Actin-mediated Cell Contraction Negative Regulation Of Macrophage Fusion Inhibitory G-protein Coupled Receptor Phosphorylation Negative Regulation Of Ion Transmembrane Transport Protein Complex Disassembly Gene Expression Muscle Contraction Negative Regulation Of Transmembrane Transport Regulation Of Cell Development Nervous System Development Establishment Of Protein Localization To Membrane Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Defense Response Actin Filament-based Movement Cellular Protein Localization Cellular Localization Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Activation Of Meiosis Involved In Egg Activation Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Sequestering Of Calcium Ion Protein Localization Regulation Of Cardiac Muscle Contraction
Tagcloud ?		aav abcc8 adeno administrations cxcl12 cxcl13 damaged foxa2 g6pc2 gad1 glp glucosamine glut2 isl1 islets neurod1 nitrosourea nkx6 nptx2 pdx1 preserve prss53 sdf slc2a2 slc30a8 stz tmem229b ttc28 ucn3	abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3
Tagcloud (Difference) ?		aav adeno administrations cxcl12 cxcl13 damaged foxa2 g6pc2 gad1 glp glucosamine glut2 isl1 islets neurod1 nitrosourea nkx6 nptx2 pdx1 preserve prss53 sdf slc2a2 slc30a8 stz tmem229b ttc28 ucn3	acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3
Tagcloud (Intersection) ?		abcc8