FKBP1B and CAMK2D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FKBP1B	CAMK2D
Description		FKBP prolyl isomerase 1B	calcium/calmodulin dependent protein kinase II delta
Image
GO Annotations	Cellular Component	Cytoplasm Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Calcium Channel Regulator Activity Protein Binding FK506 Binding Isomerase Activity Calcium Channel Inhibitor Activity Transmembrane Transporter Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Heart Rate Protein Folding 'de Novo' Protein Folding Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Glucose Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neuronal Action Potential Propagation Calcium-mediated Signaling Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Refolding T Cell Proliferation Negative Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Protein Maturation Response To Redox State Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Neuronal Synaptic Plasticity Relaxation Of Cardiac Muscle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Protein Localization To Plasma Membrane
Pathways		Stimuli-sensing channels Ion homeostasis	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Fostamatinib
Diseases
GWAS		Chronotype ( 27494321) Quantitative traits ( 19197348)	Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 24292274 28165464) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 28552196) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Small vessel stroke (CCS and TOAST classification) ( 32047268) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		12 interacting genes: ADAMTSL4 BMPR1A CAMK2D GMCL1 KRT31 KRT40 KRTAP1-1 REL RYR2 RYR3 TGFBR1 TRIM69	30 interacting genes: ACTN2 ARL2BP BANP CAMK2B CD5 CREM EPHA10 ERCC8 FAM171B FKBP1B FNDC3B GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RNF4 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TNPO3 TTC5 UBC UBE2I VIM WASF3
Entrez ID		2281	817
HPRD ID		02795	09653
Ensembl ID		ENSG00000119782	ENSG00000145349
Uniprot IDs		F8W6G9 P68106	A0A8V8TN60 A0A8V8TN65 A0A8V8TN88 A0A8V8TNA1 A0A8V8TNA7 A0A8V8TPJ8 A0A8V8TPY4 A0A994J516 A0A994J5B0 D6R938 E9PBG7 E9PF82 Q13557
PDB IDs		1C9H 4C02 4IQ2 4IQC 5HKG 5L1D 5T15 5T9M 5T9N 5T9R 5T9S 5T9V 5TA3 5TAL 5TAM 5TAN 5TAP 5TAQ 5TAS 5TAT 5TAU 5TAV 5TAW 5TAX 5TAY 5TAZ 5TB0 5TB1 5TB2 5TB3 5TB4 6JGZ 6JH6 6JHN 6JI0 6JI8 6JII 6JIU 6JIY 6JRR 6JRS 6M2W 6PV6 6W1N 6WOT 6WOU 6WOV 6X32 6X33 6X34 6X35 6X36 7CF9 7JMF 7JMG 7JMH 7JMI 7JMJ 7M6A 7M6L 7T64 7T65 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 7VML 7VMM 7VMN 7VMO 7VMP 7VMQ 7VMR 7VMS 8DTY 8DTZ 8DUJ 8DVE 8DVV 8SEN 8SEO 8SEP 8SEQ 8SER 8SES 8SET 8UQ2 8UQ3 8UQ4 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM 8XJI 8XKH 8XLF 8XLH 8Y40 9C1E 9C1F 9CGP 9CGQ	2VN9 2W2C 2WEL 3GP2 5VLO 6AYW 7ZRP 7ZRQ 8USO
Enriched GO Terms of Interacting Partners?		Ventricular Cardiac Muscle Tissue Morphogenesis Tissue Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type I Sarcoplasmic Reticulum Membrane Calcium-induced Calcium Release Activity Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Ventricular Compact Myocardium Morphogenesis Sarcoplasmic Reticulum Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Caffeine Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Transmembrane Receptor Protein Serine/threonine Kinase Activity Cellular Response To Purine-containing Compound Keratin Filament Ventricular Trabecula Myocardium Morphogenesis Sarcoplasmic Reticulum Calcium Ion Transport Response To Caffeine Sarcolemma Smooth Endoplasmic Reticulum Heart Trabecula Morphogenesis Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of The Force Of Heart Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Intermediate Filament Regulation Of Cardiac Muscle Cell Action Potential Calcium-mediated Signaling Monoatomic Cation Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calmodulin Binding Cellular Response To Alkaloid Ventricular Septum Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Intracellular Chemical Homeostasis Positive Regulation Of SMAD Protein Signal Transduction Calcium Ion Homeostasis SMAD Binding Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Neural Crest Cell Differentiation Neural Plate Mediolateral Regionalization	Cytoplasm Nuclear Matrix
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