TIPARP

Description		TCDD inducible poly(ADP-ribose) polymerase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Metal Ion Binding NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Vasculogenesis Kidney Development Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Roof Of Mouth Development Face Morphogenesis Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Central corneal thickness ( 29760442) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronotype ( 30696823) Epithelial ovarian cancer ( 25581431) Femur bone mineral density x serum urate levels interaction ( 34046847) Malaria ( 31844061) Nose size ( 27182965) Ovarian cancer ( 20852632) Testicular germ cell tumor ( 28604732) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		3 interacting genes: ATM RNF10 XRN2
Entrez ID		25976
HPRD ID		18192
Ensembl ID		ENSG00000163659
Uniprot IDs		Q05BQ2 Q7Z3E1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Monoubiquitination Establishment Of RNA Localization To Telomere MRNA Catabolic Process Establishment Of Protein-containing Complex Localization To Telomere RNA Catabolic Process Positive Regulation Of Telomerase Catalytic Core Complex Assembly Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Transcription Termination Site Sequence-specific DNA Binding DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion 5'-3' RNA Exonuclease Activity Peptidyl-serine Autophosphorylation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Nucleobase-containing Compound Catabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Telomere Capping Response To Nitrosative Stress Catabolic Process Negative Regulation Of Schwann Cell Proliferation Termination Of RNA Polymerase II Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomere Localization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To X-ray 1-phosphatidylinositol-3-kinase Activity 5'-3' Exonuclease Activity DNA Binding Lipoprotein Catabolic Process Ubiquitin-dependent Protein Catabolic Process DNA Repair Complex Female Meiotic Nuclear Division Oocyte Development Modification-dependent Protein Catabolic Process Extrinsic Component Of Synaptic Vesicle Membrane Regulation Of Telomere Capping Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Pexophagy Regulation Of Cellular Response To Heat Negative Regulation Of B Cell Proliferation Histone MRNA Catabolic Process V(D)J Recombination Gamete Generation Proteasomal Protein Catabolic Process
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