FDXR and FDX1

Number of citations of the paper that reports this interaction (PubMedID 1917982)
0

Data Source:
HPRD (in vitro)

		FDXR	FDX1
Description		ferredoxin reductase	ferredoxin 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Ferredoxin-NADP+ Reductase Activity Oxidoreductase Activity	Iron Ion Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Lipid Metabolic Process Steroid Biosynthetic Process Ubiquinone Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Cellular Response To CAMP P450-containing Electron Transport Chain Cellular Response To Forskolin
Pathways		Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR Protein lipoylation
Drugs		Flavin adenine dinucleotide Nicotinamide adenine dinucleotide phosphate	Mitotane
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Cognitive function ( 24684796) Coronary artery disease ( 32469254) Serum metabolite levels ( 33031748)
Interacting Genes		5 interacting genes: FDX1 FHIT MTNR1A OGT POU2F1	5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2
Entrez ID		2232	2230
HPRD ID		00060	00059
Ensembl ID		ENSG00000161513	ENSG00000137714
Uniprot IDs		A0A0A0MSZ4 A0A0A0MT64 A0A0A0MTN9 A0A0A0MTR6 A0A0C4DFN8 A0A0C4DGN7 P22570	P10109
PDB IDs			3N9Y 3N9Z 3NA0 3NA1 3P1M 7M8I
Enriched GO Terms of Interacting Partners?		Adenylylsulfatase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Diadenosine Triphosphate Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly P450-containing Electron Transport Chain Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Circadian Rhythm Negative Regulation Of Proteolysis Bis(5'-adenosyl)-triphosphatase Activity Protein O-acetylglucosaminyltransferase Activity Diadenosine Polyphosphate Catabolic Process Adenosine 5'-monophosphoramidase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Melatonin Receptor Activity Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbon Catabolite Regulation Of Transcription Rhythmic Process Regulation Of Transcription By Glucose NSL Complex Cellular Response To Forskolin Regulation Of Proteolysis Negative Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Hormone Binding Response To Forskolin Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	C21-steroid Hormone Biosynthetic Process Steroid Metabolic Process Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Ketone Metabolic Process Alcohol Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Regulation Of RIG-I Signaling Pathway Negative Regulation Of Necroptotic Process Cholesterol Metabolic Process Heme Binding Sterol Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Olefinic Compound Metabolic Process C21-steroid Hormone Metabolic Process Mitochondrial Inner Membrane Steroid Hormone Biosynthetic Process Regulation Of Necroptotic Process Non-canonical NF-kappaB Signal Transduction Ketone Biosynthetic Process Hormone Metabolic Process Regulation Of Programmed Necrotic Cell Death Hormone Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lipid Biosynthetic Process Oxidoreductase Activity Lipid Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Ferredoxin-NADP+ Reductase Activity 11-cis-retinol Dehydrogenase (NAD+) Activity Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Monooxygenase Activity FBXO Family Protein Binding Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Corticosterone 18-monooxygenase Activity Negative Regulation Of Postsynaptic Density Organization MHC Class Ib Protein Complex Binding Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein-containing Complex Binding Small Molecule Metabolic Process Positive Regulation Of Protein K48-linked Ubiquitination
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