FDXR

Gene Name		ferredoxin reductase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Ferredoxin-NADP+ Reductase Activity Protein Binding NADPH-adrenodoxin Reductase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Ubiquinone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: FDX1 FHIT POU2F1
Entrez ID		2232
HPRD ID		00060
Ensembl ID		ENSG00000161513
Uniprot IDs		P22570 Q6GSK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Olfactory Placode Formation Lens Induction In Camera-type Eye
Tagcloud ?		biomarker ccng1 cis constructed curves ddb2 documented dose doses estimate evident fit fulfill gy individual inter ionizing irradiated linear mgy polynomial proportionality ranges reproducibility requirements responsive transcriptionally variability variation