ALDOA and ALDOC

Number of citations of the paper that reports this interaction (PMID 22863883)
15

Data Source:
BioGRID (two hybrid, biochemical)

		ALDOA	ALDOC
Gene Name		aldolase A, fructose-bisphosphate	aldolase C, fructose-bisphosphate
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Extracellular Vesicular Exosome	Mitochondrion Cytosol Cytoskeleton Axon Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Identical Protein Binding Poly(A) RNA Binding Fructose Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Platelet Degranulation Carbohydrate Metabolic Process Fructose Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Blood Coagulation Regulation Of Cell Shape Pathogenesis Platelet Activation Fructose 1,6-bisphosphate Metabolic Process Small Molecule Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization	Response To Hypoxia Carbohydrate Metabolic Process Fructose Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Apoptotic Process Aging Pathogenesis Response To Organonitrogen Compound Response To Organic Cyclic Compound Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation Organ Regeneration Small Molecule Metabolic Process Protein Homotetramerization Protein Heterotetramerization
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Glycolysis Platelet degranulation Platelet activation, signaling and aggregation Metabolism of carbohydrates	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		1,6-Fructose Diphosphate (Linear Form) 1,3-Dihydroxyacetonephosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ADRB2 ALDOB ALDOC ATP6V1E1 BCAT2 CACNA1A DYNLL1 EGFR FANCA GALNT6 GPD2 IFNA4 MLH1 MYOC PCNA PIAS4 PLD2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	6 interactors: ALDOA ATP6V1E1 LNX1 MAP2K3 PLD2 SQLE
Entrez ID		226	230
HPRD ID		00070	02386
Ensembl ID		ENSG00000149925	ENSG00000109107
Uniprot IDs		P04075	P09972
PDB IDs		1ALD 2ALD 4ALD	1XFB
Enriched GO Terms of Interacting Partners?		Protein Complex Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Fructose 1,6-bisphosphate Metabolic Process Glucose Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Cellular Component Assembly Skeletal Muscle Adaptation Hexose Metabolic Process Monosaccharide Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Stimulus Fructose Metabolic Process Catabolic Process Cell Cycle G2/M Transition Of Mitotic Cell Cycle Homeostatic Process Organ Development Regulation Of DNA Replication Cellular Protein Complex Assembly Protein Sumoylation Cell Cycle Process Carbohydrate Catabolic Process Mitotic Cell Cycle Process Cellular Response To Dexamethasone Stimulus Carbohydrate Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Developmental Process Response To Dexamethasone Cellular Metabolic Process Mitotic Cell Cycle Response To Stress System Development Salivary Gland Morphogenesis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Vasodilation Salivary Gland Development Metal Ion Homeostasis Positive Regulation Of Signal Transduction Isoleucine Catabolic Process Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Positive Regulation Of Deoxyribonuclease Activity Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Striated Muscle Contraction
Tagcloud ?		actb aldr catb catd catg co3 conceptus cst6 gd1b gda gdi2 gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	1c2 acads acat1 adipocyte adiposity aldolase altogether anxa2 aop1 apoa1 apparoach bisphosphate calorie droplet fabp4 ffa fructose glut4 hadh intensities ketoreductase proteome proteomics scaffolding spot tubb5 underscore vimentin
Tagcloud (Difference) ?		actb aldr catb catd catg co3 conceptus cst6 gd1b gda gdi2 gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	1c2 acads acat1 adipocyte adiposity aldolase altogether anxa2 aop1 apoa1 apparoach bisphosphate calorie droplet fabp4 ffa fructose glut4 hadh intensities ketoreductase proteome proteomics scaffolding spot tubb5 underscore vimentin
Tagcloud (Intersection) ?