ALDOC and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ALDOC	MAP2K3
Description		aldolase, fructose-bisphosphate C	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Fructose Metabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation	MAPK Cascade Regulation Of Cytokine Production Response To Ischemia Inflammatory Response Signal Transduction Heart Development Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Maturation Cardiac Muscle Contraction Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To UV-B Cellular Response To Sorbitol Cellular Senescence Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
Pathways		Neutrophil degranulation Glycolysis Gluconeogenesis	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs			Fostamatinib Pimasertib
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		9 interacting genes: ANKS1A ATP6V1E1 CFTR ERBB2 FMR1 LNX1 MAP2K3 PLD2 SQLE	53 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		230	5606
HPRD ID		02386	03816
Ensembl ID		ENSG00000109107	ENSG00000034152
Uniprot IDs		A0A024QZ64 P09972	P46734 Q6FI23
PDB IDs		1XFB
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex, Catalytic Domain Cholesterol Biosynthetic Process Regulation Of Transmembrane Transporter Activity Developmental Maturation Positive Regulation Of Anion Channel Activity Steroid Biosynthetic Process Sterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding PDZ Domain Binding Regulation Of Monoatomic Ion Transmembrane Transporter Activity ERBB3:ERBB2 Complex Dendritic Filopodium Histone H3 Reader Activity Positive Regulation Of Intracellular Transport Of Viral Material Cellular Response To Sorbitol Squalene Monooxygenase Activity Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Hepatoblast Differentiation Regulation Of Pronephros Size Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Monoatomic Anion Transport RNA Polymerase I Core Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Response To Biphenyl Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Proton-transporting Two-sector ATPase Complex Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Tooth Mineralization Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Lipid Biosynthetic Process Cell Maturation Regulation Of Vesicle-mediated Transport Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding Presynaptic Membrane	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Kinase Activity Regulation Of Cell Cycle MAP Kinase Kinase Kinase Activity Regulation Of Intracellular Signal Transduction Animal Organ Development Developmental Process Regulation Of Cell Population Proliferation Regulation Of Cellular Component Organization Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Communication Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Cell Differentiation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Cytosol Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Metabolic Process Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Apoptotic Process
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