CYP11B2 and CYP11B1

Number of citations of the paper that reports this interaction (PubMedID 10411633)
0

Data Source:
HPRD (in vitro)

		CYP11B2	CYP11B1
Description		cytochrome P450 family 11 subfamily B member 2	cytochrome P450 family 11 subfamily B member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Monooxygenase Activity Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Corticosterone 18-monooxygenase Activity	Monooxygenase Activity Steroid 11-beta-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Corticosterone 18-monooxygenase Activity
	Biological Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Immune Response Cholesterol Metabolic Process Regulation Of Blood Pressure Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Glucose Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes CMO-1 deficiency	Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B1 causes AH4
Drugs		Spironolactone Levoketoconazole Osilodrostat	Mitotane Metyrapone Levoketoconazole Osilodrostat
Diseases		Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency Glucocorticoid-remediable aldosteronism (GRA)	Glucocorticoid-remediable aldosteronism (GRA) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Congenital adrenal hyperplasia (CAH)
GWAS		Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518 32709000) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)	Hypertension ( 30487518) Mean arterial pressure ( 30487518) Pulse pressure ( 30487518) Systolic blood pressure ( 29403010)
Interacting Genes		3 interacting genes: CYP11A1 CYP11B1 FDX1	1 interacting genes: CYP11B2
Entrez ID		1585	1584
HPRD ID		00492	01943
Ensembl ID		ENSG00000179142	ENSG00000160882
Uniprot IDs		P19099	P15538 Q8TDD0
PDB IDs		4DVQ 4FDH 4ZGX 6XZ8 6XZ9 7M8I 7M8V	6M7X 7E7F
Enriched GO Terms of Interacting Partners?		Hormone Biosynthetic Process Cholesterol Metabolic Process Iron Ion Binding Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Sterol Metabolic Process C21-steroid Hormone Biosynthetic Process Hormone Metabolic Process Glucocorticoid Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Lipid Biosynthetic Process Regulation Of Hormone Levels Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Ketone Metabolic Process Cellular Response To Oxygen-containing Compound Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Olefinic Compound Metabolic Process Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid 11-beta-monooxygenase Activity Corticosterone 18-monooxygenase Activity P450-containing Electron Transport Chain Aldosterone Biosynthetic Process Small Molecule Metabolic Process Mineralocorticoid Biosynthetic Process Mitochondrion Aldosterone Metabolic Process Cortisol Biosynthetic Process Response To Peptide Hormone Cellular Response To Hormone Stimulus Mitochondrial Matrix Mitochondrial Inner Membrane Vitamin D Metabolic Process Cellular Response To Potassium Ion Cellular Response To Forskolin Steroid Hydroxylase Activity Oxidoreductase Activity Response To Forskolin Regulation Of Biological Quality Response To Potassium Ion Response To Hormone 2 Iron, 2 Sulfur Cluster Binding Ketone Biosynthetic Process	Aldosterone Metabolic Process Mineralocorticoid Biosynthetic Process Steroid 11-beta-monooxygenase Activity Cortisol Biosynthetic Process Aldosterone Biosynthetic Process Regulation Of Blood Volume By Renal Aldosterone Glucocorticoid Biosynthetic Process Cortisol Metabolic Process Corticosterone 18-monooxygenase Activity Steroid Hydroxylase Activity C21-steroid Hormone Biosynthetic Process Positive Regulation Of Systemic Arterial Blood Pressure Cellular Response To Potassium Ion Glucocorticoid Metabolic Process Renal Water Homeostasis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Response To Potassium Ion Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Multicellular Organismal-level Water Homeostasis C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Positive Regulation Of Blood Pressure Ketone Biosynthetic Process Hormone Biosynthetic Process Sodium Ion Homeostasis Potassium Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Aldehyde Metabolic Process Multicellular Organismal-level Chemical Homeostasis Ketone Metabolic Process Steroid Biosynthetic Process Cholesterol Metabolic Process Heme Binding Iron Ion Binding Renal System Process Sterol Metabolic Process Olefinic Compound Metabolic Process Regulation Of Blood Pressure Cellular Response To Metal Ion Cellular Response To Peptide Hormone Stimulus Hormone Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process Regulation Of Body Fluid Levels Response To Peptide Hormone Response To Metal Ion Cellular Response To Hormone Stimulus Inorganic Ion Homeostasis
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