CYP11B2 and CYP11B1

Number of citations of the paper that reports this interaction (PMID 10411633)
0

Data Source:
HPRD (in vitro)

		CYP11B2	CYP11B1
Gene Name		cytochrome P450, family 11, subfamily B, polypeptide 2	cytochrome P450, family 11, subfamily B, polypeptide 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Heme Binding Corticosterone 18-monooxygenase Activity	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Heme Binding
	Biological Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Mineralocorticoid Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Cellular Response To Potassium Ion Small Molecule Metabolic Process Potassium Ion Homeostasis Sodium Ion Homeostasis Oxidation-reduction Process	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Xenobiotic Metabolic Process Immune Response Steroid Metabolic Process Regulation Of Blood Pressure Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Cellular Response To Potassium Ion Glucose Homeostasis Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Glucocorticoid biosynthesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			Mitotane Metyrapone
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CYP11A1 CYP11B1 FDX1	1 interactors: CYP11B2
Entrez ID		1585	1584
HPRD ID		00492	01943
Ensembl ID		ENSG00000179142	ENSG00000160882
Uniprot IDs		P19099	P15538 Q4VAR0 Q8TDD0
PDB IDs		4DVQ 4FDH
Enriched GO Terms of Interacting Partners?		C21-steroid Hormone Biosynthetic Process C21-steroid Hormone Metabolic Process Hormone Biosynthetic Process Steroid Biosynthetic Process Sterol Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Alcohol Metabolic Process Lipid Biosynthetic Process Cellular Ketone Metabolic Process Cholesterol Metabolic Process Cellular Response To Metal Ion Cellular Response To Inorganic Substance Lipid Metabolic Process Response To Genistein Oxidation-reduction Process Cortisol Biosynthetic Process Granulosa Cell Differentiation Aldosterone Biosynthetic Process Fractalkine Metabolic Process Response To Metal Ion Response To Fungicide Chemokine Metabolic Process Response To Hydroxyisoflavone Testosterone Biosynthetic Process Mineralocorticoid Biosynthetic Process Phthalate Metabolic Process Cellular Response To Potassium Ion Dibenzo-p-dioxin Metabolic Process Small Molecule Metabolic Process Biphenyl Metabolic Process Glucocorticoid Biosynthetic Process Response To Potassium Ion Response To Inorganic Substance Response To L-ascorbic Acid Estrogen Biosynthetic Process Progesterone Biosynthetic Process Vitamin D Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Androgen Biosynthetic Process Cellular Response To Hormone Stimulus Response To Insecticide Cellular Response To Cadmium Ion Glucocorticoid Metabolic Process Response To Vitamin E Leydig Cell Differentiation	Regulation Of Blood Volume By Renal Aldosterone Cortisol Biosynthetic Process Aldosterone Biosynthetic Process Mineralocorticoid Biosynthetic Process Cellular Response To Potassium Ion Glucocorticoid Biosynthetic Process Response To Potassium Ion Positive Regulation Of Systemic Arterial Blood Pressure Potassium Ion Homeostasis Glucocorticoid Metabolic Process C21-steroid Hormone Biosynthetic Process Sodium Ion Homeostasis Renal Water Homeostasis C21-steroid Hormone Metabolic Process Positive Regulation Of Blood Pressure Multicellular Organismal Water Homeostasis Hormone Biosynthetic Process Water Homeostasis Cellular Ketone Metabolic Process Regulation Of Systemic Arterial Blood Pressure Renal System Process Steroid Biosynthetic Process Cellular Response To Metal Ion Sterol Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Inorganic Substance Response To Xenobiotic Stimulus Regulation Of Blood Pressure Hormone Metabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Blood Circulation Response To Metal Ion Alcohol Metabolic Process Metal Ion Homeostasis Response To Inorganic Substance Lipid Biosynthetic Process Ion Homeostasis Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Chemical Homeostasis
Tagcloud ?		344t accentuated adrenal aldosterone consequential constitute corroborated disequilibrium haplotype haplotypes hprt hypertension hypothesize investigators linkage milieu pathophysiological permissive polymorphism predisposes pressure proinflammatory salt serves snps stemming tg ttc	11beta availability beta1 bioactive catalyzed conversion cortisol cortisone crs cytochrome dehydrogenase depend glucocorticoids hsd hsd1 hsd2 hydroxysteroid interfering measurement mucosa nasal p450 polypeptide polyps rhinosinusitis sinus steroidogenic subfamily
Tagcloud (Difference) ?		344t accentuated adrenal aldosterone consequential constitute corroborated disequilibrium haplotype haplotypes hprt hypertension hypothesize investigators linkage milieu pathophysiological permissive polymorphism predisposes pressure proinflammatory salt serves snps stemming tg ttc	11beta availability beta1 bioactive catalyzed conversion cortisol cortisone crs cytochrome dehydrogenase depend glucocorticoids hsd hsd1 hsd2 hydroxysteroid interfering measurement mucosa nasal p450 polypeptide polyps rhinosinusitis sinus steroidogenic subfamily
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