CYP11B2

Description		cytochrome P450 family 11 subfamily B member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Monooxygenase Activity Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Corticosterone 18-monooxygenase Activity
	Biological Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes CMO-1 deficiency
Drugs		Spironolactone Levoketoconazole Osilodrostat
Diseases		Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency Glucocorticoid-remediable aldosteronism (GRA)
GWAS		Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518 32709000) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)
Interacting Genes		3 interacting genes: CYP11A1 CYP11B1 FDX1
Entrez ID		1585
HPRD ID		00492
Ensembl ID		ENSG00000179142
Uniprot IDs		P19099
PDB IDs		4DVQ 4FDH 4ZGX 6XZ8 6XZ9 7M8I 7M8V
Enriched GO Terms of Interacting Partners?		Hormone Biosynthetic Process Cholesterol Metabolic Process Iron Ion Binding Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Sterol Metabolic Process C21-steroid Hormone Biosynthetic Process Hormone Metabolic Process Glucocorticoid Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Lipid Biosynthetic Process Regulation Of Hormone Levels Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Ketone Metabolic Process Cellular Response To Oxygen-containing Compound Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Olefinic Compound Metabolic Process Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid 11-beta-monooxygenase Activity Corticosterone 18-monooxygenase Activity P450-containing Electron Transport Chain Aldosterone Biosynthetic Process Small Molecule Metabolic Process Mineralocorticoid Biosynthetic Process Mitochondrion Aldosterone Metabolic Process Cortisol Biosynthetic Process Response To Peptide Hormone Cellular Response To Hormone Stimulus Mitochondrial Matrix Mitochondrial Inner Membrane Vitamin D Metabolic Process Cellular Response To Potassium Ion Cellular Response To Forskolin Steroid Hydroxylase Activity Oxidoreductase Activity Response To Forskolin Regulation Of Biological Quality Response To Potassium Ion Response To Hormone 2 Iron, 2 Sulfur Cluster Binding Ketone Biosynthetic Process
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