FCGR2A and LIMK2

Data Source: HiPPIP (Novel)

		FCGR2A	LIMK2
Name		Fc gamma receptor IIa	LIM domain kinase 2
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Nucleus Cytoplasm Cis-Golgi Network Centrosome Spindle Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Protein Binding IgG Receptor Activity IgG Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs		Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab	Fostamatinib
Diseases		Systemic lupus erythematosus	None
GWAS		Ankylosing spondylitis ( 23749187 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173 ) Helicobacter pylori serologic status ( 23652523 ) Hematocrit ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 28067908 23128233 ) Kawasaki disease ( 33772158 28886140 22081228 ) Lipid metabolism phenotypes ( 22286219 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Rheumatoid arthritis ( 30423114 24390342 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463 ) Takayasu arteritis ( 23830517 ) Ulcerative colitis ( 28067908 19915573 21297633 20228799 )	Eosinophil count ( 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Fish- and plant-related diet ( 32066663 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of granulocytes ( 27863252 ) Oily fish consumption ( 32066663 ) Paclitaxel-induced neuropathy ( 23776197 ) Pork consumption ( 32066663 ) Red cell distribution width ( 32888494 ) Sum eosinophil basophil counts ( 27863252 ) Type 2 diabetes nephropathy ( 21150874 )
Novel Interactors		11 novel interactors: ACTR2 F5 FAM3B FCER1A FCER1G FCGR2B FCGR3A LIMK2 MGST3 TARDBP TMCO1	1 novel interactors: FCGR2A
Interacting Genes		26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2	12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
Entrez ID		2212	3985
HPRD ID		00906	03585
Ensembl ID		ENSG00000143226	ENSG00000182541
Uniprot IDs		A0A8V8TPS4 P12318	P53671
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA	1X6A 4TPT 5NXD 7QHG 8GI4 8S3X 8WSW
GO Terms Enriched among Interactors		Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity	Lamellipodium Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Cytoskeleton Organization Protein Serine Kinase Activity Protein Phosphorylation Internode Region Of Axon Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Protein Kinase Activity Actin Filament Depolymerization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Actin Filament Severing Regulation Of Multicellular Organismal Process Myelination Axon Ensheathment Kinase Activity Actomyosin Structure Organization Positive Regulation Of Multicellular Organismal Process Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cytosol Organelle Organization Regulation Of Proteolysis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Immune System Process Muscle Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Focal Adhesion Assembly Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Regulation Of Multicellular Organismal Development Protein Depolymerization Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death