FCGR2A and FCER1A

		FCGR2A	FCER1A
Description		Fc gamma receptor IIa	Fc epsilon receptor Ia
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding IgG Receptor Activity IgG Binding	Protein Binding High-affinity IgE Receptor Activity IgE Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Type I Hypersensitivity Fc-epsilon Receptor Signaling Pathway Type 2 Immune Response Mast Cell Degranulation Eosinophil Degranulation
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis	Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs		Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab	Omalizumab Benzylpenicilloyl polylysine TNX-901
Diseases		Systemic lupus erythematosus
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)	C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)
Interacting Genes		26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2	6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB
Entrez ID		2212	2205
HPRD ID		00906	00917
Ensembl ID		ENSG00000143226	ENSG00000179639
Uniprot IDs		A0A8V8TPS4 P12318	E9PRN1 P12319
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA	1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q 7SHT 8C1B 8C1C 8K7R 8YVU 8YWA 8Z0T 9EQ3 9EQ4
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity	Fc-epsilon Receptor I Complex IgE Binding IgG Binding Fc-gamma Receptor Signaling Pathway Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Phagocytosis IgE Receptor Activity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Phagocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Localization Within Membrane Serotonin Secretion By Platelet Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Pyruvate Dehydrogenase (acetyl-transferring) Activity Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Leukocyte Mediated Immunity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Endocytosis Positive Regulation Of Mast Cell Cytokine Production Regulation Of Mast Cell Apoptotic Process Lamin Filament Nuclear Pore Localization Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane IgG Receptor Activity Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Interleukin-3-mediated Signaling Pathway Mast Cell Activation Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Mesenchymal Cell Proliferation Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Protein Localization To Cell Periphery Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ventricular Cardiac Muscle Cell Development
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