FAM209A and NCR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM209A	NCR3
Description		family with sequence similarity 209 member A	natural cytotoxicity triggering receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Immune Receptor Activity
	Biological Process	Spermatogenesis Cell Differentiation	Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Inflammatory Response Immune Response Cell Recognition Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity NK T Cell Activation
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Heschl's gyrus morphology ( 25130324)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 30226566) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Malaria ( 31844061) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 19079260)
Interacting Genes		258 interacting genes: ADGRE2 ADIPOQ AGTRAP AIG1 ALG8 ANKRD46 APMAP APOC3 APOD APOL2 APOL3 AQP1 AQP2 AQP3 ARLN ARV1 ASGR1 ATP13A1 B4GALNT2 BDNF BET1 BIK BMP10 BNIP2 BNIP3 BTN2A2 C11orf24 C14orf180 C1GALT1 C2 C3orf52 CANT1 CCL4L2 CD53 CD59 CD81 CDIPT CDS1 CDS2 CLCA4 CLDN19 CLDN2 CLDN4 CLDND2 CLEC4G CLN6 CMTM7 CNIH1 CNPY3 COL4A5 COL8A2 COMT CTRL CTSA CTXN3 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 DEFB121 DEFB128 DNAJC30 DOLK EBP EMC6 EMD ENTPD3 EOGT ERG28 ERMP1 FA2H FAM20B FAM3C FATE1 FCER1G FDFT1 FIS1 FUNDC2 FXYD3 FXYD6 GAST GET3 GHITM GIMAP1 GIMAP5 GJB2 GKN1 GKN2 GOSR2 GPR108 GPR151 GPR152 GPR37L1 GYPA HACD2 HHATL HMOX1 HMOX2 HTATIP2 IGFBP5 INSIG2 JAGN1 KIR2DL3 LAT LHFPL5 LPAR3 LRP10 MAL MARCHF2 MFF MFSD6 MGLL MIP MMD MMD2 MS4A1 MS4A13 MYADM MYADML2 NAPB NAT8 NCR3 NINJ2 NKG7 NRM NXPE3 OLFM4 ORMDL1 ORMDL3 OTOR PAQR7 PEDS1-UBE2V1 PEX16 PGAP2 PGLYRP3 PLLP PLN PLP1 PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 PTCH1 RHAG RPRM RTP2 RUSF1 S100A2 SACM1L SCARF1 SCD SCGB1D1 SCRG1 SEC22A SEC22B SEC61G SELENOK SEMA6C SERP1 SFTPC SLC13A3 SLC1A1 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC35E3 SLC35G2 SLC38A7 SLC39A2 SLC41A1 SLC52A2 SLC7A14 SMAGP SMCO4 SMIM1 SNORC STATH STRIT1 STX12 STX1B STX3 STX5 STX8 SYNGR1 SYT15 SYT15B TECR TEX264 TF TFRC THBD THSD7B TM6SF2 TMBIM6 TMEM100 TMEM107 TMEM11 TMEM120A TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM236 TMEM239 TMEM243 TMEM254 TMEM42 TMEM43 TMEM47 TMEM50B TMEM60 TMEM65 TMEM72 TMEM79 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TNF TNFRSF10C TNMD TRAF3IP3 TRAM1L1 TRARG1 TREX1 TSPAN2 TSPAN33 TSPAN7 TSPO TWSG1 UBE2J1 UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1 VMP1 VSTM1 WFDC2 WFS1 YIPF4 YIPF6 ZFPL1	5 interacting genes: BAG6 CD247 CD59 FAM209A FCER1G
Entrez ID		200232	259197
HPRD ID		18536	11384
Ensembl ID		ENSG00000124103	ENSG00000204475
Uniprot IDs		Q5JX71	O14931 Q05D23
PDB IDs			3NOI 3PV6 6YJP 9FWW
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Plasma Membrane SNARE Complex Golgi Apparatus Chemical Homeostasis Golgi Membrane Membrane Organization Vesicle Fusion Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Response To Mercury Ion Organelle Membrane Fusion Membrane Fusion Organelle Fusion Lipid Metabolic Process Localization Within Membrane Cholesterol Binding Multicellular Organismal-level Chemical Homeostasis Establishment Of Protein Localization To Membrane Lipid Biosynthetic Process Intracellular Chemical Homeostasis Vesicle-mediated Transport Sterol Biosynthetic Process Establishment Of Protein Localization Water Channel Activity SNARE Binding Membrane Docking Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Protein Localization To Membrane Ankyrin-1 Complex Glycerol Transmembrane Transport Paracellular Transport Nuclear Inner Membrane Sterol Metabolic Process Response To Bacterium Renal Water Transport Renal Water Homeostasis Intracellular Monoatomic Ion Homeostasis Heme Metabolic Process Protein Localization To Cell Periphery Organelle Localization By Membrane Tethering Glycerol Transmembrane Transporter Activity Phosphatidate Cytidylyltransferase Activity Cholesterol Biosynthetic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity	Fc-gamma Receptor III Complex Activation Of Immune Response Positive Regulation Of Immune Response Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface T Cell Activation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Tertiary Granule Membrane Lymphocyte Activation IgE Receptor Activity Leukocyte Activation Alpha-beta T Cell Activation Regulation Of Immune System Process Cell Activation Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Immune System Process Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Positive Regulation Of Type III Hypersensitivity BAT3 Complex Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Maintenance Of Unfolded Protein Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Transmembrane Signaling Receptor Activity Alpha-beta T Cell Receptor Complex Complement Binding Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Internal Peptidyl-lysine Acetylation NK T Cell Activation
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