FAM209A and WFS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM209A	WFS1
Description		family with sequence similarity 209 member A	wolframin ER transmembrane glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Transport Vesicle Secretory Granule Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding Calmodulin Binding Ubiquitin Protein Ligase Binding Calcium-dependent Protein Binding ATPase Binding Proteasome Binding DNA-binding Transcription Factor Binding Protein Carrier Chaperone
	Biological Process	Spermatogenesis Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Pancreas Development Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction ERAD Pathway Olfactory Behavior Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ERAD Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Wolfram syndrome (WFS); DIDMOAD syndrome Type II diabetes mellitus
GWAS		Heschl's gyrus morphology ( 25130324)	Cisplatin-induced ototoxicity ( 28039263) High density lipoprotein cholesterol levels ( 32902719) Medication use (drugs used in diabetes) ( 31015401) Mild age-related type 2 diabetes ( 34737425) Type 2 diabetes ( 20581827 32499647 31118516 30718926 30297969 30054458 29632382 29358691 28869590 24509480 22885922 19734900) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		258 interacting genes: ADGRE2 ADIPOQ AGTRAP AIG1 ALG8 ANKRD46 APMAP APOC3 APOD APOL2 APOL3 AQP1 AQP2 AQP3 ARLN ARV1 ASGR1 ATP13A1 B4GALNT2 BDNF BET1 BIK BMP10 BNIP2 BNIP3 BTN2A2 C11orf24 C14orf180 C1GALT1 C2 C3orf52 CANT1 CCL4L2 CD53 CD59 CD81 CDIPT CDS1 CDS2 CLCA4 CLDN19 CLDN2 CLDN4 CLDND2 CLEC4G CLN6 CMTM7 CNIH1 CNPY3 COL4A5 COL8A2 COMT CTRL CTSA CTXN3 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 DEFB121 DEFB128 DNAJC30 DOLK EBP EMC6 EMD ENTPD3 EOGT ERG28 ERMP1 FA2H FAM20B FAM3C FATE1 FCER1G FDFT1 FIS1 FUNDC2 FXYD3 FXYD6 GAST GET3 GHITM GIMAP1 GIMAP5 GJB2 GKN1 GKN2 GOSR2 GPR108 GPR151 GPR152 GPR37L1 GYPA HACD2 HHATL HMOX1 HMOX2 HTATIP2 IGFBP5 INSIG2 JAGN1 KIR2DL3 LAT LHFPL5 LPAR3 LRP10 MAL MARCHF2 MFF MFSD6 MGLL MIP MMD MMD2 MS4A1 MS4A13 MYADM MYADML2 NAPB NAT8 NCR3 NINJ2 NKG7 NRM NXPE3 OLFM4 ORMDL1 ORMDL3 OTOR PAQR7 PEDS1-UBE2V1 PEX16 PGAP2 PGLYRP3 PLLP PLN PLP1 PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 PTCH1 RHAG RPRM RTP2 RUSF1 S100A2 SACM1L SCARF1 SCD SCGB1D1 SCRG1 SEC22A SEC22B SEC61G SELENOK SEMA6C SERP1 SFTPC SLC13A3 SLC1A1 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC35E3 SLC35G2 SLC38A7 SLC39A2 SLC41A1 SLC52A2 SLC7A14 SMAGP SMCO4 SMIM1 SNORC STATH STRIT1 STX12 STX1B STX3 STX5 STX8 SYNGR1 SYT15 SYT15B TECR TEX264 TF TFRC THBD THSD7B TM6SF2 TMBIM6 TMEM100 TMEM107 TMEM11 TMEM120A TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM236 TMEM239 TMEM243 TMEM254 TMEM42 TMEM43 TMEM47 TMEM50B TMEM60 TMEM65 TMEM72 TMEM79 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TNF TNFRSF10C TNMD TRAF3IP3 TRAM1L1 TRARG1 TREX1 TSPAN2 TSPAN33 TSPAN7 TSPO TWSG1 UBE2J1 UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1 VMP1 VSTM1 WFDC2 WFS1 YIPF4 YIPF6 ZFPL1	11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1
Entrez ID		200232	7466
HPRD ID		18536	05864
Ensembl ID		ENSG00000124103	ENSG00000109501
Uniprot IDs		Q5JX71	A0A0S2Z4V6 O76024
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Plasma Membrane SNARE Complex Golgi Apparatus Chemical Homeostasis Golgi Membrane Membrane Organization Vesicle Fusion Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Response To Mercury Ion Organelle Membrane Fusion Membrane Fusion Organelle Fusion Lipid Metabolic Process Localization Within Membrane Cholesterol Binding Multicellular Organismal-level Chemical Homeostasis Establishment Of Protein Localization To Membrane Lipid Biosynthetic Process Intracellular Chemical Homeostasis Vesicle-mediated Transport Sterol Biosynthetic Process Establishment Of Protein Localization Water Channel Activity SNARE Binding Membrane Docking Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Protein Localization To Membrane Ankyrin-1 Complex Glycerol Transmembrane Transport Paracellular Transport Nuclear Inner Membrane Sterol Metabolic Process Response To Bacterium Renal Water Transport Renal Water Homeostasis Intracellular Monoatomic Ion Homeostasis Heme Metabolic Process Protein Localization To Cell Periphery Organelle Localization By Membrane Tethering Glycerol Transmembrane Transporter Activity Phosphatidate Cytidylyltransferase Activity Cholesterol Biosynthetic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity	Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Peptide Secretion Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Protein Transport Renal System Process Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity G-protein Alpha-subunit Binding Regulation Of Insulin Secretion Negative Regulation Of Secretion Regulation Of Catecholamine Secretion Regulation Of Peptide Hormone Secretion Nitrate Transmembrane Transporter Activity Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Protein Localization To Plasma Membrane Assembly Of Large Subunit Precursor Of Preribosome Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Engulfment Of Target By Autophagosome Negative Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization PH-gated Chloride Channel Activity Nitrate Transmembrane Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protein Localization To Cell Periphery Septin Cytoskeleton Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Leukotriene B4 Receptor Activity Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Amine Transport Alpha2-adrenergic Receptor Activity Regulation Of Body Fluid Levels Negative Regulation Of Activation Of Membrane Attack Complex IgM B Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway
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