FABP2 and AGR2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		FABP2	AGR2
Description		fatty acid binding protein 2	anterior gradient 2, protein disulphide isomerase family member
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microvillus Apical Cortex	Extracellular Region Extracellular Space Endoplasmic Reticulum
	Molecular Function	Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Binding Protein Binding Lipid Binding Long-chain Fatty Acid Binding	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Fatty Acid Metabolic Process Fatty Acid Transport Long-chain Fatty Acid Transport Intestinal Absorption Intestinal Lipid Absorption	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Triglyceride catabolism
Drugs		Ibuprofen Dexibuprofen
Diseases
GWAS		Refractive error ( 32231278)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		4 interacting genes: AGR2 ALDH1B1 CFTR TERF2IP	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		2169	10551
HPRD ID		00611	05896
Ensembl ID		ENSG00000145384	ENSG00000106541
Uniprot IDs		P12104	O95994 Q4JM46
PDB IDs		1KZW 1KZX 2MJI 2MO5 3AKM 3IFB 6L7K	2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Lung Goblet Cell Differentiation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Enamel Mineralization Positive Regulation Of PERK-mediated Unfolded Protein Response Alcohol Metabolic Process Response To Endoplasmic Reticulum Stress Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Regulation Of Body Fluid Levels Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Protection From Non-homologous End Joining At Telomere Shelterin Complex Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of IRE1-mediated Unfolded Protein Response Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Dystroglycan Binding Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Ethanol Metabolic Process Aldehyde Dehydrogenase (NAD+) Activity Ethanol Catabolic Process Regulation Of Monoatomic Anion Transport Cellular Response To Stress Epithelial Fluid Transport Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Chromosome, Telomeric Region Telomere Capping Golgi-associated Vesicle Membrane Telomere Maintenance In Response To DNA Damage Cellular Response To Forskolin Mucus Secretion Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization Response To Forskolin Positive Regulation Of Cell Communication Positive Regulation Of Signaling Chloride Transmembrane Transporter Activity Sperm Capacitation Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor	Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway
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