GGCX and F9

Number of citations of the paper that reports this interaction (PubMedID 11133752)
0

Data Source:
HPRD (in vivo)

		GGCX	F9
Description		gamma-glutamyl carboxylase	coagulation factor IX
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Gamma-glutamyl Carboxylase Activity Lyase Activity Vitamin Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Blood Coagulation Protein Modification Process Vitamin K Metabolic Process Negative Regulation Of Neurotransmitter Secretion Protein Maturation Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process	Proteolysis Blood Coagulation Hemostasis Zymogen Activation
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Protein hydroxylation Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Venous thromboembolism ( 31676865)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		2677	2158
HPRD ID		00665	02385
Ensembl ID		ENSG00000115486	ENSG00000101981
Uniprot IDs		A0A8I5QJA4 P38435	P00740
PDB IDs		9BUM 9BUR 9BUX 9BVK 9BVL 9BVM 9BVO 9BVP 9BVQ 9BVR	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P 7AHV 8EPC 8EPH 8EPK 8OL9 9BVK 9BVR
Enriched GO Terms of Interacting Partners?		Golgi Lumen Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Serine-type Endopeptidase Activity Calcium Ion Binding Regulation Of Blood Coagulation Regulation Of Hemostasis Endopeptidase Activity Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Response To Vitamin K Response To Hydroxyisoflavone Regulation Of Response To Wounding Response To Phenylpropanoid Positive Regulation Of Wound Healing Peptidase Activity Extracellular Region Protein Metabolic Process Proteolysis Protein Processing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cytotoxic T Cell Differentiation Negative Regulation Of Coagulation Response To Astaxanthin Hydrolase Activity Response To Estrogen Golgi Cisterna Membrane Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Wound Healing Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Golgi Calcium Ion Transport Golgi Calcium Ion Homeostasis P-type Manganese Transporter Activity Trans-Golgi Network Membrane Organization Response To Vitamin Protein Maturation Positive Regulation Of TOR Signaling Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Iron Chaperone Activity Ferroxidase Activity	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Golgi Lumen Positive Regulation Of Blood Coagulation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Coagulation Acute-phase Response Protein Maturation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Hemostasis Regulation Of Blood Coagulation Endopeptidase Activity Response To Astaxanthin Gamma-glutamyl Carboxylase Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Calcium Ion Binding Serine-type Peptidase Activity Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Regulation Of Wound Healing Serine-type Endopeptidase Activity Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Negative Regulation Of Testosterone Biosynthetic Process Lipoprotein Particle Receptor Binding Regulation Of Response To Wounding Thrombospondin Receptor Activity Response To Genistein Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Neutrophil-mediated Killing Of Gram-negative Bacterium Response To Thyroxine Response To Vitamin K Response To Hydroxyisoflavone Positive Regulation Of Lysosomal Protein Catabolic Process Response To L-phenylalanine Derivative Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Phenylpropanoid Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process
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