GGCX and FXN

		GGCX	FXN
Description		gamma-glutamyl carboxylase	frataxin
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Gamma-glutamyl Carboxylase Activity Lyase Activity Vitamin Binding	Ferroxidase Activity Protein Binding Enzyme Activator Activity Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Iron Chaperone Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Blood Coagulation Protein Modification Process Vitamin K Metabolic Process Negative Regulation Of Neurotransmitter Secretion Protein Maturation Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process	Oxidative Phosphorylation Heme Biosynthetic Process Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Iron-sulfur Cluster Assembly Protein Autoprocessing Proprioception Intracellular Monoatomic Cation Homeostasis Mitochondrial Respiratory Chain Complex III Assembly Organ Growth Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Negative Regulation Of Organ Growth Muscle Cell Cellular Homeostasis Positive Regulation Of Lyase Activity Protein Maturation Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Inorganic Ion Homeostasis
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle Complex III assembly
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Friedreich ataxia
GWAS		Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	7 interacting genes: ACTN1 AKT1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126
Entrez ID		2677	2395
HPRD ID		00665	06013
Ensembl ID		ENSG00000115486	ENSG00000165060
Uniprot IDs		A0A8I5QJA4 P38435	A0A0S2Z3G4 Q16595
PDB IDs		9BUM 9BUR 9BUX 9BVK 9BVL 9BVM 9BVO 9BVP 9BVQ 9BVR	1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU 8PK8 8PK9 8RME
Enriched GO Terms of Interacting Partners?		Golgi Lumen Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Serine-type Endopeptidase Activity Calcium Ion Binding Regulation Of Blood Coagulation Regulation Of Hemostasis Endopeptidase Activity Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Response To Vitamin K Response To Hydroxyisoflavone Regulation Of Response To Wounding Response To Phenylpropanoid Positive Regulation Of Wound Healing Peptidase Activity Extracellular Region Protein Metabolic Process Proteolysis Protein Processing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cytotoxic T Cell Differentiation Negative Regulation Of Coagulation Response To Astaxanthin Hydrolase Activity Response To Estrogen Golgi Cisterna Membrane Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Wound Healing Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Golgi Calcium Ion Transport Golgi Calcium Ion Homeostasis P-type Manganese Transporter Activity Trans-Golgi Network Membrane Organization Response To Vitamin Protein Maturation Positive Regulation Of TOR Signaling Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Iron Chaperone Activity Ferroxidase Activity	Protein K29-linked Ubiquitination Mitochondrial Calcium Ion Transmembrane Transport Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Postsynapse Organization Platelet Morphogenesis Structural Constituent Of Postsynapse Protein Modification Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Protein Metabolic Process Protein Maturation Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Steroid Metabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Phospholipid Binding Membrane Curvature Sensor Activity Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Processing Peptidase Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Cellular Response To Decreased Oxygen Levels Actin Filament Binding Fascia Adherens Actin Filament Network Formation Response To Rapamycin Cellular Response To Oxygen Levels Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Calcium Ion Transmembrane Transport Negative Regulation Of Fatty Acid Beta-oxidation
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