F10 and GGCX

Number of citations: 0 (PubMedID 9538022)
Data Source: HPRD (in vitro)

		F10	GGCX
Name		coagulation factor X	gamma-glutamyl carboxylase
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane External Side Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Phospholipid Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Gamma-glutamyl Carboxylase Activity Lyase Activity Vitamin Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling	Blood Coagulation Protein Modification Process Vitamin K Metabolic Process Negative Regulation Of Neurotransmitter Secretion Protein Maturation Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process
Pathways		Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs		Antihemophilic factor, human recombinant IIa Recombinant Human Coagulation Factor IX (Recombinant) Fondaparinux Heparin Enoxaparin gamma-carboxy-L-glutamic acid 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE SSR-126517E LY-517717 Rivaroxaban Lanoteplase Idraparinux rNAPc2 Apixaban Otamixaban Eribaxaban (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE GW-813893 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE 5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE Edoxaban Turoctocog alfa Protamine sulfate Bemiparin Kappadione Antithrombin Alfa Betrixaban Nafamostat Protein S human Coagulation factor VII human Anti-inhibitor coagulant complex Coagulation Factor IX Human Antihemophilic factor human Albutrepenonacog alfa Emicizumab Nonacog beta pegol Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol	IIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases		None	Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bipolar disorder ( 31043756 ) Blood protein levels ( 30072576 ) Factor VII ( 17903294 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 )	Coronary artery disease ( 26343387 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) High light scatter reticulocyte count ( 32888494 ) Myocardial infarction ( 26343387 ) Prostate cancer ( 21743467 ) Triglyceride levels ( 32203549 )
Novel Interactors		None recorded	7 novel interactors: ARFGAP1 ATP2C1 CD8A FXN PDCD5 PPM1G ST3GAL4
Interacting Genes		23 interacting genes: APOH CAMP F2 F3 F5 F7 F8 GAD2 GGCX H1-2 MGST3 NBPF19 NOTCH2NLA PLAT PLG PRKAB1 PROS1 SERPINA10 SERPINA5 SERPINB6 SERPINB8 TFPI UBQLN2	7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2
Entrez ID		2159	2677
HPRD ID		01966	00665
Ensembl ID		ENSG00000126218	ENSG00000115486
Uniprot IDs		P00742 Q5JVE7 Q5JVE8	A0A8I5QJA4 P38435
PDB IDs		1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1NFU 1NFW 1NFX 1NFY 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2D1J 2EI6 2EI7 2EI8 2FZZ 2G00 2GD4 2H9E 2J2U 2J34 2J38 2J4I 2J94 2J95 2JKH 2P16 2P3F 2P3T 2P3U 2P93 2P94 2P95 2PHB 2PR3 2Q1J 2RA0 2UWL 2UWO 2UWP 2VH0 2VH6 2VVC 2VVU 2VVV 2VWL 2VWM 2VWN 2VWO 2W26 2W3I 2W3K 2WYG 2WYJ 2XBV 2XBW 2XBX 2XBY 2XC0 2XC4 2XC5 2Y5F 2Y5G 2Y5H 2Y7X 2Y7Z 2Y80 2Y81 2Y82 3CEN 3CS7 3ENS 3FFG 3HPT 3IIT 3K9X 3KL6 3KQB 3KQC 3KQD 3KQE 3LIW 3M36 3M37 3Q3K 3SW2 3TK5 3TK6 4A7I 4BTI 4BTT 4BTU 4Y6D 4Y71 4Y76 4Y79 4Y7A 4Y7B 4ZH8 4ZHA 5JQY 5JTC 5JZ8 5JZU 5K0H 5VOE 5VOF 6Q9F 6Q9I 6RK9 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7AHU 7BMI 7BMJ 7E6J 7TPP 7YB8 7YB9 7YBB 7YBC 8EOK 8RE5 8RE6 8RE7 8RE8 8RE9 9BVL 9CLI 9CM2 9CM9 9CTH	9BUM 9BUR 9BUX 9BVK 9BVL 9BVM 9BVO 9BVP 9BVQ 9BVR
GO Terms Enriched among Interactors		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Response To Wounding Negative Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Extracellular Region Regulation Of Fibrinolysis Fibrinolysis Extracellular Matrix Serine-type Endopeptidase Inhibitor Activity Protein Maturation Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Platelet Alpha Granule Lumen Serine-type Peptidase Complex Endoplasmic Reticulum Lumen Protein Processing Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Biological Quality Golgi Lumen Trans-synaptic Signaling By BDNF Protease Binding Biological Process Involved In Interaction With Symbiont Response To Vitamin K Serine Protease Inhibitor Complex Serine-type Peptidase Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Heparin Binding Plasminogen Activation Cytolysis By Host Of Symbiont Cells Trans-synaptic Signaling, Modulating Synaptic Transmission Extracellular Exosome Endopeptidase Activity Leukotriene Biosynthetic Process Platelet Alpha Granule Protein Activation Cascade Carboxylic Acid Biosynthetic Process	Golgi Lumen Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Serine-type Endopeptidase Activity Calcium Ion Binding Regulation Of Blood Coagulation Regulation Of Hemostasis Endopeptidase Activity Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Response To Vitamin K Response To Hydroxyisoflavone Regulation Of Response To Wounding Response To Phenylpropanoid Positive Regulation Of Wound Healing Peptidase Activity Extracellular Region Protein Metabolic Process Proteolysis Protein Processing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cytotoxic T Cell Differentiation Negative Regulation Of Coagulation Response To Astaxanthin Hydrolase Activity Response To Estrogen Golgi Cisterna Membrane Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Wound Healing Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Golgi Calcium Ion Transport Golgi Calcium Ion Homeostasis P-type Manganese Transporter Activity Trans-Golgi Network Membrane Organization Response To Vitamin Protein Maturation Positive Regulation Of TOR Signaling Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Iron Chaperone Activity Ferroxidase Activity