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F10
Description
coagulation factor X
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
External Side Of Plasma Membrane
Molecular Function
Serine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Biological Process
Proteolysis
Blood Coagulation
Hemostasis
Positive Regulation Of Cell Migration
Positive Regulation Of TOR Signaling
Pathways
Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Defective factor IX causes thrombophilia
Defective cofactor function of FVIIIa variant
Defective F9 variant does not activate FX
Drugs
Antihemophilic factor, human recombinant
IIa Recombinant Human
Coagulation Factor IX (Recombinant)
Fondaparinux
Heparin
Enoxaparin
gamma-carboxy-L-glutamic acid
4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
SSR-126517E
LY-517717
Rivaroxaban
Lanoteplase
Idraparinux
rNAPc2
Apixaban
Otamixaban
Eribaxaban
(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE
2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE
GW-813893
2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE
N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE
N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE
N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE
5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE
5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE
6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE
6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE
5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide
5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide
5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide
N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE
1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE
5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE
5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE
5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE
3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE
4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE
Edoxaban
Turoctocog alfa
Protamine sulfate
Bemiparin
Kappadione
Antithrombin Alfa
Betrixaban
Nafamostat
Protein S human
Coagulation factor VII human
Anti-inhibitor coagulant complex
Coagulation Factor IX Human
Antihemophilic factor human
Albutrepenonacog alfa
Emicizumab
Nonacog beta pegol
Lonoctocog alfa
Moroctocog alfa
Turoctocog alfa pegol
Diseases
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
30072576
)
Factor VII (
17903294
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Interacting Genes
23 interacting genes:
APOH
CAMP
F2
F3
F5
F7
F8
GAD2
GGCX
H1-2
MGST3
NBPF19
NOTCH2NLA
PLAT
PLG
PRKAB1
PROS1
SERPINA10
SERPINA5
SERPINB6
SERPINB8
TFPI
UBQLN2
Entrez ID
2159
HPRD ID
01966
Ensembl ID
ENSG00000126218
Uniprot IDs
P00742
Q5JVE7
Q5JVE8
PDB IDs
1C5M
1EZQ
1F0R
1F0S
1FAX
1FJS
1FXY
1G2L
1G2M
1HCG
1IOE
1IQE
1IQF
1IQG
1IQH
1IQI
1IQJ
1IQK
1IQL
1IQM
1IQN
1KSN
1LPG
1LPK
1LPZ
1LQD
1MQ5
1MQ6
1NFU
1NFW
1NFX
1NFY
1P0S
1V3X
1WU1
1XKA
1XKB
1Z6E
2BMG
2BOH
2BOK
2BQ6
2BQ7
2BQW
2CJI
2D1J
2EI6
2EI7
2EI8
2FZZ
2G00
2GD4
2H9E
2J2U
2J34
2J38
2J4I
2J94
2J95
2JKH
2P16
2P3F
2P3T
2P3U
2P93
2P94
2P95
2PHB
2PR3
2Q1J
2RA0
2UWL
2UWO
2UWP
2VH0
2VH6
2VVC
2VVU
2VVV
2VWL
2VWM
2VWN
2VWO
2W26
2W3I
2W3K
2WYG
2WYJ
2XBV
2XBW
2XBX
2XBY
2XC0
2XC4
2XC5
2Y5F
2Y5G
2Y5H
2Y7X
2Y7Z
2Y80
2Y81
2Y82
3CEN
3CS7
3ENS
3FFG
3HPT
3IIT
3K9X
3KL6
3KQB
3KQC
3KQD
3KQE
3LIW
3M36
3M37
3Q3K
3SW2
3TK5
3TK6
4A7I
4BTI
4BTT
4BTU
4Y6D
4Y71
4Y76
4Y79
4Y7A
4Y7B
4ZH8
4ZHA
5JQY
5JTC
5JZ8
5JZU
5K0H
5VOE
5VOF
6Q9F
6Q9I
6RK9
6YYW
6YYX
6YYY
6Z6Q
6Z6R
7AHU
7BMI
7BMJ
7E6J
7TPP
7YB8
7YB9
7YBB
7YBC
8EOK
8RE5
8RE6
8RE7
8RE8
8RE9
9BVL
9CLI
9CM2
9CM9
9CTH
Enriched GO Terms of Interacting Partners
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Coagulation
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Regulation Of Blood Coagulation
Regulation Of Hemostasis
Positive Regulation Of Blood Coagulation
Positive Regulation Of Coagulation
Regulation Of Wound Healing
Extracellular Space
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Regulation Of Response To Wounding
Negative Regulation Of Coagulation
Positive Regulation Of Wound Healing
Negative Regulation Of Wound Healing
Negative Regulation Of Fibrinolysis
Extracellular Region
Regulation Of Fibrinolysis
Fibrinolysis
Extracellular Matrix
Serine-type Endopeptidase Inhibitor Activity
Protein Maturation
Peptidase Inhibitor Activity
Serine-type Endopeptidase Activity
Platelet Alpha Granule Lumen
Serine-type Peptidase Complex
Endoplasmic Reticulum Lumen
Protein Processing
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Regulation Of Biological Quality
Golgi Lumen
Trans-synaptic Signaling By BDNF
Protease Binding
Biological Process Involved In Interaction With Symbiont
Response To Vitamin K
Serine Protease Inhibitor Complex
Serine-type Peptidase Activity
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Blood Coagulation, Intrinsic Pathway
Heparin Binding
Plasminogen Activation
Cytolysis By Host Of Symbiont Cells
Trans-synaptic Signaling, Modulating Synaptic Transmission
Extracellular Exosome
Endopeptidase Activity
Leukotriene Biosynthetic Process
Platelet Alpha Granule
Protein Activation Cascade
Carboxylic Acid Biosynthetic Process
Tagcloud
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