F10 and SERPINB6

Number of citations of the paper that reports this interaction (PubMedID 8136380)
0

Data Source:
HPRD (in vitro)

		F10	SERPINB6
Description		coagulation factor X	serpin family B member 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Phospholipid Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Proteolysis Blood Coagulation Hemostasis Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling	Sensory Perception Of Sound Cellular Response To Osmotic Stress
Pathways		Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX	Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Antihemophilic factor, human recombinant IIa Recombinant Human Coagulation Factor IX (Recombinant) Fondaparinux Heparin Enoxaparin gamma-carboxy-L-glutamic acid 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE SSR-126517E LY-517717 Rivaroxaban Lanoteplase Idraparinux rNAPc2 Apixaban Otamixaban Eribaxaban (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE GW-813893 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE 5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE Edoxaban Turoctocog alfa Protamine sulfate Bemiparin Kappadione Antithrombin Alfa Betrixaban Nafamostat Protein S human Coagulation factor VII human Anti-inhibitor coagulant complex Coagulation Factor IX Human Antihemophilic factor human Albutrepenonacog alfa Emicizumab Nonacog beta pegol Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol	Drotrecogin alfa
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Factor VII ( 17903294) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)	Chronic lymphocytic leukemia ( 26956414) Crohn's disease ( 32581322)
Interacting Genes		23 interacting genes: APOH CAMP F2 F3 F5 F7 F8 GAD2 GGCX H1-2 MGST3 NBPF19 NOTCH2NLA PLAT PLG PRKAB1 PROS1 SERPINA10 SERPINA5 SERPINB6 SERPINB8 TFPI UBQLN2	8 interacting genes: F10 F2 KLK2 MYCBP2 PLAU PLG PROC SUMO2
Entrez ID		2159	5269
HPRD ID		01966	01413
Ensembl ID		ENSG00000126218	ENSG00000124570
Uniprot IDs		P00742 Q5JVE7 Q5JVE8	A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237
PDB IDs		1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1NFU 1NFW 1NFX 1NFY 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2D1J 2EI6 2EI7 2EI8 2FZZ 2G00 2GD4 2H9E 2J2U 2J34 2J38 2J4I 2J94 2J95 2JKH 2P16 2P3F 2P3T 2P3U 2P93 2P94 2P95 2PHB 2PR3 2Q1J 2RA0 2UWL 2UWO 2UWP 2VH0 2VH6 2VVC 2VVU 2VVV 2VWL 2VWM 2VWN 2VWO 2W26 2W3I 2W3K 2WYG 2WYJ 2XBV 2XBW 2XBX 2XBY 2XC0 2XC4 2XC5 2Y5F 2Y5G 2Y5H 2Y7X 2Y7Z 2Y80 2Y81 2Y82 3CEN 3CS7 3ENS 3FFG 3HPT 3IIT 3K9X 3KL6 3KQB 3KQC 3KQD 3KQE 3LIW 3M36 3M37 3Q3K 3SW2 3TK5 3TK6 4A7I 4BTI 4BTT 4BTU 4Y6D 4Y71 4Y76 4Y79 4Y7A 4Y7B 4ZH8 4ZHA 5JQY 5JTC 5JZ8 5JZU 5K0H 5VOE 5VOF 6Q9F 6Q9I 6RK9 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7AHU 7BMI 7BMJ 7E6J 7TPP 7YB8 7YB9 7YBB 7YBC 8EOK 8RE5 8RE6 8RE7 8RE8 8RE9 9BVL 9CLI 9CM2 9CM9 9CTH
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Response To Wounding Negative Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Extracellular Region Regulation Of Fibrinolysis Fibrinolysis Extracellular Matrix Serine-type Endopeptidase Inhibitor Activity Protein Maturation Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Platelet Alpha Granule Lumen Serine-type Peptidase Complex Endoplasmic Reticulum Lumen Protein Processing Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Biological Quality Golgi Lumen Trans-synaptic Signaling By BDNF Protease Binding Biological Process Involved In Interaction With Symbiont Response To Vitamin K Serine Protease Inhibitor Complex Serine-type Peptidase Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Heparin Binding Plasminogen Activation Cytolysis By Host Of Symbiont Cells Trans-synaptic Signaling, Modulating Synaptic Transmission Extracellular Exosome Endopeptidase Activity Leukotriene Biosynthetic Process Platelet Alpha Granule Protein Activation Cascade Carboxylic Acid Biosynthetic Process	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Coagulation Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Peptidase Activity Negative Regulation Of Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Protein Metabolic Process Regulation Of Response To Wounding Proteolysis Positive Regulation Of Wound Healing Endopeptidase Activity Extracellular Space Golgi Lumen External Side Of Plasma Membrane Hydrolase Activity Macromolecule Metabolic Process Protein Processing Extracellular Region Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Biological Quality Endoplasmic Reticulum Lumen Protein Maturation Regulation Of Proteolysis Regulation Of Locomotion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Multicellular Organismal Process Blood Microparticle Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Receptor Ligand Activity Positive Regulation Of Cell Migration Negative Regulation Of Proteolysis Thrombospondin Receptor Activity Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell-matrix Adhesion Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis
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