SIX4

Description		SIX homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of Synaptic Assembly At Neuromuscular Junction Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Gene Expression Male Sex Determination Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Sarcomere Organization Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Sex Differentiation Thymus Development Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Skeletal Muscle Fiber Differentiation Negative Regulation Of Satellite Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: EYA2 EYA3
Entrez ID		51804
HPRD ID		06960
Ensembl ID		ENSG00000100625
Uniprot IDs		Q9UIU6
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA Repair Phosphoprotein Phosphatase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of DNA Metabolic Process Mesodermal Cell Fate Specification Regulation Of Cellular Response To Stress DNA Repair Mitochondrial Outer Membrane Permeabilization Chromatin Remodeling DNA Metabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death DNA Damage Response Chromatin Organization Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Membrane Permeability Cellular Response To Stress Hydrolase Activity Cell Fate Specification Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitochondrial Membrane Organization Nucleic Acid Metabolic Process Striated Muscle Tissue Development Response To Ionizing Radiation Muscle Tissue Development Cell Differentiation Nucleobase-containing Compound Metabolic Process Visual Perception
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