SIX4 and EYA3

Number of citations of the paper that reports this interaction (PMID 10490620)
53

Data Source:
HPRD (in vitro)

		SIX4	EYA3
Gene Name		SIX homeobox 4	EYA transcriptional coactivator and phosphatase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Chromatin Binding Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Metal Ion Binding
	Biological Process	Transcription, DNA-templated Skeletal Muscle Tissue Development Regulation Of Synaptic Growth At Neuromuscular Junction Male Gonad Development Anatomical Structure Morphogenesis Male Sex Determination Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Sarcomere Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Male Sex Differentiation Thymus Development Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Skeletal Muscle Fiber Differentiation Negative Regulation Of Satellite Cell Differentiation	Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: EYA2 EYA3	6 interactors: DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		51804	2140
HPRD ID		06960	09042
Ensembl ID		ENSG00000100625	ENSG00000158161
Uniprot IDs		Q9UIU6	Q99504
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Histone Modification Dephosphorylation Mesodermal Cell Fate Specification DNA Repair Chromatin Modification Mitochondrial Outer Membrane Permeabilization Chromatin Organization Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Mesodermal Cell Fate Commitment Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Chromosome Organization DNA Metabolic Process Mesodermal Cell Differentiation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of DNA Repair Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Mitochondrial Membrane Organization Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Mitochondrial Changes Mesoderm Formation Mesoderm Morphogenesis Cell Fate Specification Extrinsic Apoptotic Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Response To DNA Damage Stimulus Formation Of Primary Germ Layer Response To Ionizing Radiation Mesoderm Development Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Mitochondrial Transport Visual Perception Sensory Perception Of Light Stimulus Phosphate-containing Compound Metabolic Process Gastrulation Organelle Organization RNA Metabolic Process Cellular Protein Modification Process Response To Stress	Regulation Of Branching Involved In Ureteric Bud Morphogenesis Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Olfactory Placode Formation Trigeminal Ganglion Development Regulation Of Satellite Cell Proliferation Metanephros Development Ear Morphogenesis Embryonic Skeletal System Morphogenesis Myoblast Migration Fungiform Papilla Morphogenesis Sensory Organ Development Regulation Of Cell Proliferation Embryonic Skeletal System Development Fungiform Papilla Development Ganglion Development Protein Localization To Nucleus Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Regulation Of Organ Morphogenesis Tongue Morphogenesis Nose Development Pharyngeal System Development Mesenchyme Development Middle Ear Morphogenesis Ear Development Positive Regulation Of Embryonic Development Skeletal System Morphogenesis Positive Regulation Of Kidney Development Tongue Development Kidney Development Muscle Cell Migration Embryonic Organ Morphogenesis Renal System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cranial Nerve Development Urogenital System Development Thymus Development Regulation Of Synapse Assembly Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Organ Development
Tagcloud ?		antagonistically bivalent catalysed catalysing demethylases demethylation elongation facilitates h3k27 h3k27me3 h3k4me3 lys27 lys4 marks myogenesis pcg pol polycomb recruits remove replaced repressive spreading transactivator transcribed trimethylation trithorax trxg utx
Tagcloud (Difference) ?		antagonistically bivalent catalysed catalysing demethylases demethylation elongation facilitates h3k27 h3k27me3 h3k4me3 lys27 lys4 marks myogenesis pcg pol polycomb recruits remove replaced repressive spreading transactivator transcribed trimethylation trithorax trxg utx
Tagcloud (Intersection) ?