USP45 and SPDL1

Number of citations of the paper that reports this interaction (PubMedID 30258100)
32

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		USP45	SPDL1
Description		ubiquitin specific peptidase 45	spindle apparatus coiled-coil protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Enzyme Binding Kinetochore Binding
	Biological Process	Neural Retina Development DNA Repair Proteolysis Cell Migration Protein Deubiquitination Photoreceptor Cell Maintenance Global Genome Nucleotide-excision Repair	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Chromosome Alignment Mitotic Spindle Assembly Checkpoint Signaling Cell Migration Protein Localization To Kinetochore Cell Division
Pathways		Formation of Incision Complex in GG-NER	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Erectile dysfunction ( 30297428) Pursuit maintenance gain ( 29064472)	Bipolar disorder x sex interaction ( 34099189)
Interacting Genes		8 interacting genes: BMPR1B ERCC1 MYC SMAD1 SMURF1 SPDL1 TGFBR1 UBC	10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45
Entrez ID		85015	54908
HPRD ID		11667	08623
Ensembl ID		ENSG00000123552	ENSG00000040275
Uniprot IDs		D6RBV3 Q70EL2	Q96EA4
PDB IDs			8ARF
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cartilage Development BMP Signaling Pathway Ubiquitin Protein Ligase Binding Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cartilage Development Positive Regulation Of Developmental Process Regulation Of Chromosome Organization Negative Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Regulation Of Cellular Component Organization Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Osteoblast Differentiation Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Cellular Developmental Process Positive Regulation Of DNA-templated Transcription Regulation Of Chondrocyte Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Bone Development Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Positive Regulation Of MiRNA Transcription Positive Regulation Of Cell Projection Organization Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Engulfment Of Target By Autophagosome Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Chromosome Organization Regulation Of Apoptotic Signaling Pathway Pattern Specification Process
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