NFRKB and FBP2

		NFRKB	FBP2
Description		nuclear factor related to kappaB binding protein	fructose-bisphosphatase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Ino80 Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Z Disc Extracellular Exosome Anchoring Junction
	Molecular Function	Protease Binding DNA Binding Protein Binding	Catalytic Activity Protein Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Embryonic Development Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Fructose 1,6-bisphosphate Metabolic Process
Pathways		UCH proteinases DNA Damage Recognition in GG-NER	Gluconeogenesis
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) Night sleep phenotypes ( 27126917) Reticulocyte count ( 32888494)	Caudal middle frontal gyrus volume ( 31530798) Colorectal cancer (alcohol consumption interaction) ( 27723779) Height ( 19893584)
Interacting Genes		3 interacting genes: EPHB3 NFKB1 TRDMT1	19 interacting genes: AURKA AXIN2 BMPR1A BUB1 CHD3 CTNNA1 DLC1 FBXW7 MAP2K4 MLH3 MSH2 NRAS PDGFRL PIK3CA RB1 SMAD2 SMAD4 SRC STK11
Entrez ID		4798	8789
HPRD ID		01240	04322
Ensembl ID		ENSG00000170322	ENSG00000130957
Uniprot IDs		Q6P4R8	O00757
PDB IDs		3U21 4UF5 4UF6 4WLP	3IFA 3IFC 4HE0 4HE1 4HE2 5ET5 5ET6 5ET7 5ET8 5K54 5K55 5K56 5L0A 5Q0C
Enriched GO Terms of Interacting Partners?			Regulation Of Developmental Process Axis Specification Chromosome Organization Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dorsal/ventral Axis Specification Heart Valve Morphogenesis I-SMAD Binding ATP Binding Intracellular Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Kinase Activity Organelle Organization Regulation Of Organelle Organization Activin Responsive Factor Complex Odontogenesis Protein Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Nucleotide Binding Endoderm Development Regulation Of Chromosome Organization Reproductive Process Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Cycle Anatomical Structure Morphogenesis Protein Kinase Activity Centromeric DNA Binding Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding SMAD Binding Regulation Of Cellular Component Organization Response To Growth Factor Mesendoderm Development SMAD Protein Complex Maintenance Of DNA Repeat Elements Regulation Of Signal Transduction
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