NFRKB and ST14

		NFRKB	ST14
Description		nuclear factor related to kappaB binding protein	ST14 transmembrane serine protease matriptase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Ino80 Complex	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protease Binding DNA Binding Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Embryonic Development Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Neural Tube Closure Proteolysis Protein Catabolic Process Keratinocyte Differentiation Epithelial Cell Differentiation Animal Organ Development Epithelial Cell Morphogenesis Involved In Placental Branching
Pathways		UCH proteinases DNA Damage Recognition in GG-NER	Formation of the cornified envelope Formation of the cornified envelope
Drugs			Urokinase Benzamidine Camostat
Diseases			Ichthyosis with hypotrichosis
GWAS		High light scatter reticulocyte count ( 32888494) Night sleep phenotypes ( 27126917) Reticulocyte count ( 32888494)	Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		3 interacting genes: EPHB3 NFKB1 TRDMT1	16 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF PDGFC PHB1 PLAU RAD51 RGS16 SPINT1 STK11 TGFB1
Entrez ID		4798	6768
HPRD ID		01240	06005
Ensembl ID		ENSG00000170322	ENSG00000149418
Uniprot IDs		Q6P4R8	Q9Y5Y6
PDB IDs		3U21 4UF5 4UF6 4WLP	1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T 8G1V 8G1W
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Glycoside Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Stress Regulation Of Cell Growth Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Population Proliferation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Localization Response To Radiation Positive Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Growth Negative Regulation Of Intracellular Signal Transduction Anoikis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Defense Response Positive Regulation Of MAPK Cascade
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