EPHA1 and GJB1

Number of citations of the paper that reports this interaction (PubMedID 30401746)
52

Data Source:
BioGRID (enzymatic study)

		EPHA1	GJB1
Description		EPH receptor A1	gap junction protein beta 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding Fibronectin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding	Gap Junction Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly	Cell Communication Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs		Fostamatinib
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Family history of Alzheimer's disease ( 30617256) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE	57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6
Entrez ID		2041	2705
HPRD ID		01554	02367
Ensembl ID		ENSG00000146904	ENSG00000169562
Uniprot IDs		P21709	P08034
PDB IDs		2K1K 2K1L 3HIL 3KKA	5KK9 7ZXM 7ZXN 7ZXO 7ZXP 7ZXQ 7ZXT 8QJF 8QJH 8QK6 8QKI
Enriched GO Terms of Interacting Partners?		Protein Modification Process Phosphoprotein Phosphatase Activity Phosphate-containing Compound Metabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Cell Surface Receptor Signaling Pathway Protein Metabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Engulfment Of Target By Autophagosome SMAD Binding Non-canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Negative Regulation Of T Cell Proliferation ERBB3:ERBB2 Complex ERBB Signaling Pathway Cellular Response To Mechanical Stimulus Intestinal Epithelial Cell Migration Phosphatase Activity Protein Phosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phosphorylation Notochord Formation RNA Polymerase I Core Binding Cerebellar Cortex Formation Negative Regulation Of Leukocyte Proliferation Signal Transduction Regulation Of NMDA Receptor Activity Positive Regulation Of MAPK Cascade Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Glial Cell Differentiation ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus	Membrane Plasma Membrane Membrane Raft Regulation Of Protein Localization Positive Regulation Of Protein Localization Intestinal Epithelial Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Protein Binding Endoplasmic Reticulum Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Establishment Of Protein Localization Leukocyte Activation Regulation Of Phosphorus Metabolic Process Ephrin Receptor Binding Connexin Binding Regulation Of Superoxide Metabolic Process Positive Regulation Of Protein Phosphorylation Integrin Binding Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Transport Regulation Of Blood Circulation Positive Regulation Of Endocytosis Positive Regulation Of Phosphorylation Plasma Membrane Raft Membrane Raft Distribution Regulation Of Cell Junction Assembly Cell Surface Regulation Of Calcium-mediated Signaling Cell Activation Regulation Of MAPK Cascade Signaling Receptor Activator Activity Regulation Of Protein Phosphorylation Membrane Raft Localization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of ERK1 And ERK2 Cascade
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