EPHA1 and EFNA1

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vivo, in vitro)

		EPHA1	EFNA1
Gene Name		EPH receptor A1	ephrin-A1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding Protein Kinase Binding	Receptor Binding Protein Binding Ephrin Receptor Binding
	Biological Process	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Rac GTPase Activity Activation Of Rho GTPase Activity Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Maintenance Positive Regulation Of Angiogenesis Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Negative Regulation Of Dendritic Spine Morphogenesis
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance Transcriptional regulation of pluripotent stem cells EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732)
Protein-Protein Interactions		2 interactors: EFNA1 SMURF2	14 interactors: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6
Entrez ID		2041	1942
HPRD ID		01554	01858
Ensembl ID		ENSG00000146904	ENSG00000169242
Uniprot IDs		B5A967 P21709	P20827
PDB IDs		2K1K 2K1L 3HIL 3KKA	3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Dendritic Spine Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Mitral Valve Development Ubiquitin-dependent SMAD Protein Catabolic Process Negative Regulation Of Dendrite Morphogenesis Notochord Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Dendrite Development Enzyme Linked Receptor Protein Signaling Pathway Heart Valve Formation Negative Regulation Of Epithelial To Mesenchymal Transition Atrioventricular Valve Morphogenesis Notochord Development Atrioventricular Valve Development Negative Regulation Of Transcription, DNA-templated Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Stem Cell Differentiation Heart Valve Morphogenesis Positive Regulation Of Signal Transduction Heart Valve Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Dendritic Spine Development Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter BMP Signaling Pathway Negative Regulation Of Cellular Metabolic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Dendrite Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Mesenchymal Cell Development	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Peptidyl-tyrosine Phosphorylation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Locomotion Cell Part Morphogenesis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Generation Of Neurons Neuron Differentiation Neurogenesis Cell Projection Organization Protein Phosphorylation Nervous System Development Cell Development Phosphorylation Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Anatomical Structure Morphogenesis Cellular Protein Metabolic Process Cell Differentiation Regulation Of Rac GTPase Activity Fasciculation Of Motor Neuron Axon Regulation Of Rho GTPase Activity Response To Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Stimulus Regulation Of Cell Adhesion Signal Transduction Regulation Of Rac Protein Signal Transduction Fasciculation Of Sensory Neuron Axon Regulation Of Rho Protein Signal Transduction System Development Protein Metabolic Process Regulation Of Intracellular Signal Transduction Signaling Cell Communication Multicellular Organismal Development
Tagcloud ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Difference) ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Intersection) ?