EPHA1 and SMURF1

Number of citations of the paper that reports this interaction (PubMedID 20804422)
0

Data Source:
BioGRID (enzymatic study)

		EPHA1	SMURF1
Description		EPH receptor A1	SMAD specific E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Extracellular Exosome
	Molecular Function	Nucleotide Binding Fibronectin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phospholipid Binding Transferase Activity SMAD Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding Activin Receptor Binding
	Biological Process	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Receptor Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Axon Extension Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Family history of Alzheimer's disease ( 30617256) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 23128233 28067908) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 20228798 28067908)
Interacting Genes		12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE	188 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13B DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SKIC8 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TAPT1 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WEE1 WFS1 XPO1 ZFAND5
Entrez ID		2041	57154
HPRD ID		01554	06902
Ensembl ID		ENSG00000146904	ENSG00000198742
Uniprot IDs		P21709	Q9HCE7
PDB IDs		2K1K 2K1L 3HIL 3KKA	2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Protein Modification Process Phosphoprotein Phosphatase Activity Phosphate-containing Compound Metabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Cell Surface Receptor Signaling Pathway Protein Metabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Engulfment Of Target By Autophagosome SMAD Binding Non-canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Negative Regulation Of T Cell Proliferation ERBB3:ERBB2 Complex ERBB Signaling Pathway Cellular Response To Mechanical Stimulus Intestinal Epithelial Cell Migration Phosphatase Activity Protein Phosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phosphorylation Notochord Formation RNA Polymerase I Core Binding Cerebellar Cortex Formation Negative Regulation Of Leukocyte Proliferation Signal Transduction Regulation Of NMDA Receptor Activity Positive Regulation Of MAPK Cascade Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Glial Cell Differentiation ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus	Cytosol Protein Kinase Activity Modification-dependent Protein Catabolic Process Protein Modification Process Cytoplasm Proteolysis Involved In Protein Catabolic Process Kinase Activity Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Intracellular Signaling Cassette Macromolecule Catabolic Process Protein Serine Kinase Activity Proteolysis Post-translational Protein Modification Proteasomal Protein Catabolic Process ATP Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process I-SMAD Binding Nucleotide Binding Macromolecule Metabolic Process Signal Transduction Regulation Of Proteolysis Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Nucleoplasm Protein Modification By Small Protein Conjugation Protein Phosphorylation Heteromeric SMAD Protein Complex Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Ubiquitin Binding Regulation Of Cell Communication Protein Polyubiquitination Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding
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