EPHA1

Gene Name		EPH receptor A1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding Protein Kinase Binding
	Biological Process	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Rac GTPase Activity Activation Of Rho GTPase Activity Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Maintenance Positive Regulation Of Angiogenesis Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance Transcriptional regulation of pluripotent stem cells EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841)
Protein-protein Interactions		2 interactors: EFNA1 SMURF2
Entrez ID		2041
HPRD ID		01554
Ensembl ID		ENSG00000146904
Uniprot IDs		B5A967 P21709
PDB IDs		2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Dendritic Spine Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Mitral Valve Development Ubiquitin-dependent SMAD Protein Catabolic Process Negative Regulation Of Dendrite Morphogenesis Notochord Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Dendrite Development Enzyme Linked Receptor Protein Signaling Pathway Heart Valve Formation Negative Regulation Of Epithelial To Mesenchymal Transition Atrioventricular Valve Morphogenesis Notochord Development Atrioventricular Valve Development Negative Regulation Of Transcription, DNA-templated Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Stem Cell Differentiation Heart Valve Morphogenesis Positive Regulation Of Signal Transduction Heart Valve Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Dendritic Spine Development Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter BMP Signaling Pathway Negative Regulation Of Cellular Metabolic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Dendrite Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Mesenchymal Cell Development
Tagcloud ?		abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1