BBS1 and PAX2

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		BBS1	PAX2
Gene Name		Bardet-Biedl syndrome 1	paired box 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane	Nucleus Lysosome Microtubule Organizing Center Protein-DNA Complex Centriolar Satellite Protein Complex
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Protein Binding Transcription Factor Binding Superoxide-generating NADPH Oxidase Activity Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Retina Homeostasis Organelle Organization Visual Perception Nonmotile Primary Cilium Assembly Cilium Assembly Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Protein Localization To Cilium	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Axonogenesis Mesodermal Cell Fate Specification Aging Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Pancreas Development Response To Nutrient Levels Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Oxidation-reduction Process Mesenchymal To Epithelial Transition Paramesonephric Duct Development Optic Chiasma Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Epidermal Growth Factor Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Formation Mesonephric Duct Development Nephric Duct Formation Ureter Development Ureter Morphogenesis Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Reactive Oxygen Species Metabolic Process Cochlea Development Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Alzheimer's disease ( 20061627)
Protein-Protein Interactions		13 interactors: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7	11 interactors: BBS1 BBS2 BBS4 BBS7 ID2 MAPK8 MAPK8IP1 PAXIP1 RB1 SFRP2 WT1
Entrez ID		582	5076
HPRD ID		01950	01330
Ensembl ID		ENSG00000174483	ENSG00000075891
Uniprot IDs		E7EQH1 Q32MM9 Q8NFJ9	Q02962
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Interleukin-8 Production Response To Organic Substance Cellular Response To Oxidative Stress Cellular Response To Organic Substance Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Optic Chiasma Development Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Optic Nerve Formation Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Androgen Receptor Activity Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Golgi To Plasma Membrane CFTR Protein Transport Glycolate Biosynthetic Process Methylglyoxal Catabolic Process To D-lactate Cellular Response To Glyoxal Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Dismutase Activity Cellular Protein Metabolic Process Regulation Of Heart Rate Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Peptidyl-cysteine Oxidation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Regulation Of Superoxide Dismutase Activity Positive Regulation Of Cellular Metabolic Process Response To Oxidative Stress Cellular Response To Reactive Oxygen Species	Nonmotile Primary Cilium Assembly Anatomical Structure Morphogenesis Tissue Development Tube Development Digestive Tract Development Photoreceptor Cell Maintenance Melanosome Transport Digestive System Development Pigment Granule Transport Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Establishment Of Melanosome Localization Cilium Assembly Melanosome Localization Tube Morphogenesis Visual Perception Sensory Perception Of Light Stimulus Cardiovascular System Development Cilium Organization Regulation Of Gene Expression JUN Phosphorylation Cilium Morphogenesis Heart Development Organ Morphogenesis Positive Regulation Of Growth Heart Morphogenesis Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cellular Pigmentation Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Connective Tissue Development Digestive Tract Morphogenesis Leptin-mediated Signaling Pathway Cell Projection Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Developmental Growth Organ Development Negative Regulation Of Appetite Response To Stimulus Negative Regulation Of Gene Expression Establishment Of Organelle Localization Positive Regulation Of Macrophage Differentiation Cellular Response To Leptin Stimulus Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Regulation Of Microtubule-based Movement Pigmentation Cell Differentiation Epithelial Tube Morphogenesis Striatum Development
Tagcloud ?		abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a	agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts
Tagcloud (Difference) ?		abca4 allelic audiogram c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees rd rdh12 sanger sscp tulp1 ush2a	agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts
Tagcloud (Intersection) ?