BBS1 and EIF3A

Number of citations of the paper that reports this interaction (PubMedID 18000879)
0

Data Source:
BioGRID (two hybrid)

		BBS1	EIF3A
Description		Bardet-Biedl syndrome 1	eukaryotic translation initiation factor 3 subunit A
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Centriolar Satellite BBSome Cell Projection Ciliary Membrane	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Organelle Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Signaling Receptor Binding Patched Binding Smoothened Binding Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Retina Homeostasis Lipid Metabolic Process Visual Perception Sensory Perception Of Smell Intracellular Protein Localization Photoreceptor Cell Morphogenesis Fertilization Protein Transport Dendrite Development Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Response To Endoplasmic Reticulum Stress Olfactory Behavior Hormone Metabolic Process Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Retina Development In Camera-type Eye Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Neural Precursor Cell Proliferation Protein Localization To Cilium Non-motile Cilium Assembly	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		BBSome-mediated cargo-targeting to cilium	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Bipolar disorder ( 21926972) Height ( 28552196)	Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)
Interacting Genes		13 interacting genes: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7	26 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF10 RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 WEE2-AS1 YWHAZ
Entrez ID		582	8661
HPRD ID		01950	03618
Ensembl ID		ENSG00000174483	ENSG00000107581
Uniprot IDs		Q8NFJ9	Q14152
PDB IDs		6XT9	3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Regulation Of Mitochondrial Membrane Potential Chemical Homeostasis Homeostatic Process Cellular Homeostasis Regulation Of Programmed Cell Death Regulation Of Aerobic Respiration Cytoplasm Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Cellular Respiration Cytosol Epithelial Cell Proliferation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Autophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Protein Metabolic Process Intracellular Chemical Homeostasis Regulation Of Calcium Ion Transport Into Cytosol Blood Vessel Remodeling Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process Axon Nucleus Localization Nuclear Migration Centriolar Satellite Microtubule Organizing Center Negative Regulation Of Reactive Oxygen Species Metabolic Process Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Proline Dipeptidase Activity Eye Pigmentation Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Regulation Of Translational Initiation Eukaryotic 43S Preinitiation Complex Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression RNA Binding Translation Eukaryotic Translation Initiation Factor 4F Complex RNA Strand Annealing Activity Viral Translational Termination-reinitiation BBSome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cytosol TORC1 Signaling Protein-containing Complex Organization Hippocampus Development Cytoplasm Striatum Development Negative Regulation Of Catabolic Process Regulation Of Cilium Beat Frequency Cerebral Cortex Development Regulation Of Protein Metabolic Process TOR Signaling Retina Homeostasis Protein-containing Complex Assembly Cytoplasmic Stress Granule Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Component Assembly Ventricular System Development Brain Morphogenesis Translation Factor Activity, RNA Binding Regulation Of TORC1 Signaling Translation Initiation Factor Binding Protein Metabolic Process Negative Regulation Of Autophagy Regulation Of Circadian Sleep/wake Cycle Regulation Of Biological Quality Tube Formation Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cilium Movement Adult Behavior Regulation Of Macromolecule Biosynthetic Process
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