CSF3 and CSF3R

Number of citations of the paper that reports this interaction (PMID 10364174)
5

Data Source:
HPRD (in vivo)

		CSF3	CSF3R
Gene Name		colony stimulating factor 3 (granulocyte)	colony stimulating factor 3 receptor (granulocyte)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding	Receptor Activity Cytokine Receptor Activity Protein Binding
	Biological Process	Immune Response Multicellular Organismal Development Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Actin Cytoskeleton Reorganization	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Amelogenesis
Pathways
Drugs			Pegfilgrastim Filgrastim
Diseases
GWAS		Neutrophil count ( 20172861) White blood cell count ( 20139978 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		2 interactors: CSF3R ELANE	19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		1440	1441
HPRD ID		00736	00737
Ensembl ID		ENSG00000108342	ENSG00000119535
Uniprot IDs		P09919 Q6FH65 Q8N4W3	Q99062
PDB IDs		1CD9 1GNC 1PGR 1RHG 2D9Q	1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Neutrophil Mediated Killing Of Fungus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Interleukin-8 Production Amelogenesis Cell Migration Cell Motility Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Positive Regulation Of Interleukin-8 Production Interaction With Symbiont Leukocyte Mediated Cytotoxicity Inflammatory Response To Antigenic Stimulus Locomotion Negative Regulation Of Cytokine Biosynthetic Process Defense Response Response To Fungus Movement Of Cell Or Subcellular Component Neutrophil Chemotaxis Neutrophil Migration Regulation Of Chemokine Production Granulocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Collagen Catabolic Process Positive Regulation Of Cytokine Biosynthetic Process Response To External Stimulus Acute Inflammatory Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Immune System Process Regulation Of Smooth Muscle Cell Proliferation Leukocyte Chemotaxis Negative Regulation Of Inflammatory Response Odontogenesis Of Dentin-containing Tooth Regulation Of Cytokine Biosynthetic Process Odontogenesis Response To UV Response To Organic Substance Regulation Of Chemotaxis	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune Response Leukocyte Migration Regulation Of Immune Response Response To Peptide Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Motility Immune System Process Defense Response Innate Immune Response Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organonitrogen Compound Response To Organic Substance Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Locomotion Response To Hormone Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction JAK-STAT Cascade Blood Coagulation Hemostasis Regulation Of Intracellular Signal Transduction Signal Transduction Cytokine-mediated Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Intersection) ?