EIF4G2 and EIF4A2

Number of citations of the paper that reports this interaction (PMID 17353931)
246

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EIF4G2	EIF4A2
Gene Name		eukaryotic translation initiation factor 4 gamma, 2	eukaryotic translation initiation factor 4A2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Cell Death Cytokine-mediated Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of RNA-directed RNA Polymerase Activity
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL	17 interactors: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 IPO11 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP TK1 TRIM36 TRIM39
Entrez ID		1982	1974
HPRD ID		09084	03062
Ensembl ID		ENSG00000110321	ENSG00000156976
Uniprot IDs		P78344 Q2TU89	Q14240 Q9NZE6
PDB IDs		3D3M 3L6A 4IUL	3BOR
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Translational Initiation Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Response To Cytokine Regulation Of Protein Metabolic Process Nuclear Export Gene Expression Biosynthetic Process MRNA Processing Catabolic Process MRNA Metabolic Process Cellular Response To Organic Substance Viral Process Cellular Metabolic Process RNA Processing Nucleocytoplasmic Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Transport Response To Organic Substance MRNA Export From Nucleus Lymphocyte Homeostasis Negative Regulation Of RNA-directed RNA Polymerase Activity RNA Export From Nucleus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Protein Metabolic Process Leukocyte Homeostasis Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway MRNA Transport Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus	Regulation Of Cell Cycle Centrosome Organization Microtubule Organizing Center Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Binding Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Histone H4-K16 Acetylation Fetal Process Involved In Parturition Regulation Of Translational Initiation Regulation Of JUN Kinase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Chromosome Segregation Cell Cycle Regulation Of DNA Binding Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Binding Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centriole-centriole Cohesion Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Apoptotic Process Cellular Response To Indole-3-methanol Regulation Of Mitotic Centrosome Separation Programmed Cell Death Regulation Of Cell Cycle Process Developmental Process Ribosomal Protein Import Into Nucleus Intraciliary Transport Involved In Cilium Morphogenesis Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Cell Cycle Process Regulation Of Cytoskeleton Organization Response To Ionizing Radiation Dosage Compensation By Inactivation Of X Chromosome Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization
Tagcloud ?		11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo	4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Difference) ?		11p15 backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo	adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Intersection) ?		4f