EIF4G2 and EIF5

Number of citations of the paper that reports this interaction (PMID 11331597)
38

Data Source:
HPRD (in vitro)

		EIF4G2	EIF5
Gene Name		eukaryotic translation initiation factor 4 gamma, 2	eukaryotic translation initiation factor 5
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	Translation Initiation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Cell Death Cytokine-mediated Signaling Pathway	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Red blood cell traits ( 23222517)
Protein-Protein Interactions		11 interactors: CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL	14 interactors: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 NCBP2 NRGN PUM1
Entrez ID		1982	1983
HPRD ID		09084	03417
Ensembl ID		ENSG00000110321	ENSG00000100664
Uniprot IDs		P78344 Q2TU89	P55010 Q6IBU0
PDB IDs		3D3M 3L6A 4IUL	2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Translational Initiation Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Response To Cytokine Regulation Of Protein Metabolic Process Nuclear Export Gene Expression Biosynthetic Process MRNA Processing Catabolic Process MRNA Metabolic Process Cellular Response To Organic Substance Viral Process Cellular Metabolic Process RNA Processing Nucleocytoplasmic Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Transport Response To Organic Substance MRNA Export From Nucleus Lymphocyte Homeostasis Negative Regulation Of RNA-directed RNA Polymerase Activity RNA Export From Nucleus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Protein Metabolic Process Leukocyte Homeostasis Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway MRNA Transport Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus	Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Gene Expression MRNA 3'-end Processing Protein Metabolic Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Macromolecular Complex Assembly Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Axon Guidance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Collateral Sprouting In Absence Of Injury Cytokine-mediated Signaling Pathway Male Germ Cell Proliferation Regulation Of Metabolic Process Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Axonogenesis Cellular Component Assembly Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis MRNA Catabolic Process Axon Choice Point Recognition Axon Development RNA Processing Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cytoplasmic Translational Initiation Positive Regulation Of Glucokinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Chemotaxis Adiponectin-activated Signaling Pathway
Tagcloud ?		11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo	40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr
Tagcloud (Difference) ?		11p15 4f backcross blot casein codes conserved contains copy exhibits germ glycosylation homology interspecific iso northern p82 polypeptide segment southern syntenic ubiquitously vertebrates wheat zoo	40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine tagged tif35p transiently trna u20s ydr
Tagcloud (Intersection) ?		frame reading similarity