EIF4EBP2 and LSM3

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		EIF4EBP2	LSM3
Description		eukaryotic translation initiation factor 4E binding protein 2	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleus Cytoplasm Neuronal Ribonucleoprotein Granule Postsynapse	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Translation Regulation Of Translation Memory Insulin Receptor Signaling Pathway Negative Regulation Of Translation TOR Signaling Social Behavior Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: CDK4 EIF4E FHL3 LSM3 MTOR RPTOR	45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		1979	27258
HPRD ID		03747	06283
Ensembl ID		ENSG00000148730	ENSG00000170860
Uniprot IDs		Q13542	P62310
PDB IDs		2MX4 3AM7	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Regulation Of NADP Metabolic Process Negative Regulation Of Autophagy Cellular Response To L-leucine Positive Regulation Of Mitotic Cell Cycle Response To L-leucine Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translation Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase III Positive Regulation Of ATP Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Positive Regulation Of Cell Cycle Regulation Of Glycolytic Process Translation Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Osteoclast Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Eukaryotic Initiation Factor 4G Binding Regulation Of Translation Regulation Of ATP Metabolic Process TOR Signaling Regulation Of Amide Metabolic Process Response To Osmotic Stress Regulation Of Purine Nucleotide Metabolic Process Cellular Response To Amino Acid Stimulus Regulation Of Cell Size Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of TOR Signaling Cytoplasmic Stress Granule Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle P-body Autophagosome Assembly Regulation Of TORC1 Signaling Positive Regulation Of Lipid Biosynthetic Process Autophagosome Organization Regulation Of Translational Initiation Positive Regulation Of Cell Cycle Phase Transition	RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding
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