EIF4EBP2 and MTOR

Number of citations of the paper that reports this interaction (PMID 16798736)
31

Data Source:
BioGRID (enzymatic study)

		EIF4EBP2	MTOR
Gene Name		eukaryotic translation initiation factor 4E binding protein 2	mechanistic target of rapamycin (serine/threonine kinase)
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Gene Ontology Annotations	Cellular Component		Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Phosphatidylinositol 3-kinase Complex Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Drug Binding Kinase Activity Protein Domain Specific Binding Ribosome Binding Protein Dimerization Activity Phosphoprotein Binding
	Biological Process	Translation Insulin Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Translational Initiation	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Glycogen Biosynthetic Process Protein Phosphorylation Response To Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Germ Cell Development Response To Nutrient Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Cell Growth Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Ruffle Organization Regulation Of Myelination Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Growth Response To Amino Acid Regulation Of Carbohydrate Utilization Innate Immune Response Positive Regulation Of Translation Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Regulation Of Cellular Response To Heat
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease mTOR signalling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling S6K1-mediated signalling mTORC1-mediated signalling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling S6K1-mediated signalling mTORC1-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway HSF1-dependent transactivation IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Release of eIF4E VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Release of eIF4E Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: EIF4E MTOR	42 interactors: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 EIF3F EIF4EBP1 EIF4EBP2 FKBP1A FKBP8 GPHN GSK3B IRS1 MAF1 MLST8 PA2G4 PDPK1 PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB RRAGD SEPT2 STAT3 TELO2 TERT TRAF6 UBQLN1 YWHAQ
Entrez ID		1979	2475
HPRD ID		03747	03134
Ensembl ID		ENSG00000148730	ENSG00000198793
Uniprot IDs		Q13542	B4DZD5 P42345
PDB IDs		3AM7	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Utilization Cellular Response To Insulin Stimulus Regulation Of Translation Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Response To Peptide Negative Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase III Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Macroautophagy Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Size Response To Organonitrogen Compound Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Lamellipodium Organization Regulation Of Response To Food Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Regulation Of Rac GTPase Activity TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Lamellipodium Assembly Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Cellular Response To Heat Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Myotube Differentiation Negative Regulation Of Autophagy Regulation Of Rac Protein Signal Transduction Ruffle Organization Regulation Of Glycogen Metabolic Process Positive Regulation Of Stress Fiber Assembly Peptidyl-threonine Phosphorylation Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Transcription Factor Import Into Nucleus Regulation Of Myelination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Lipid Catabolic Process Regulation Of Myotube Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Stress Fiber Assembly Cellular Response To Heat	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of TOR Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Neurotrophin Signaling Pathway Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction TOR Signaling Insulin Receptor Signaling Pathway Response To Organic Substance Regulation Of Metabolic Process Response To Organonitrogen Compound Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Positive Regulation Of TOR Signaling Phosphatidylinositol-mediated Signaling Cellular Response To Insulin Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Cell Communication Response To Insulin Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Death Response To Peptide Hormone Immune Response-regulating Signaling Pathway Signal Transduction Negative Regulation Of Cell Death Response To Peptide Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Signaling Regulation Of Immune System Process
Tagcloud ?		aa ampk biopsies bovine competition dataset elf5 emerging existence favoring frap1 gland glucose gsk3a harvested inferred lactation mammary mapk14 milk mtor pregnancy ribosomal rpl22 stat5 transcripts translational transporters tsc1	aib aminoisobutyric ars arsenite carrier hormonal hs hyperthermic instigate involve k2 km l6 map mapkap maximally metabolisable p42 p44 phosphoinositide pi3k rapamycin sapk2 sb stresses transport transporter vmax whilst wortmannin
Tagcloud (Difference) ?		aa ampk biopsies bovine competition dataset elf5 emerging existence favoring frap1 gland glucose gsk3a harvested inferred lactation mammary mapk14 milk mtor pregnancy ribosomal rpl22 stat5 transcripts translational transporters tsc1	aib aminoisobutyric ars arsenite carrier hormonal hs hyperthermic instigate involve k2 km l6 map mapkap maximally metabolisable p42 p44 phosphoinositide pi3k rapamycin sapk2 sb stresses transport transporter vmax whilst wortmannin
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