EME2 and FANCM

Number of citations of the paper that reports this interaction (PubMedID 17289582)
0

Data Source:
BioGRID (pull down)

		EME2	FANCM
Description		essential meiotic structure-specific endonuclease subunit 2	FA complementation group M
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex
	Molecular Function	DNA Binding Nuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Enzyme-substrate Adaptor Activity	Nucleotide Binding Four-way Junction DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Helicase Activity Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Replication Fork Processing Homologous Recombination Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Protein Monoubiquitination
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases			Fanconi anemia
GWAS			Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		5 interacting genes: FAAP24 FANCM MEOX2 MUS81 UBC	11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I
Entrez ID		197342	57697
HPRD ID		16859	13876
Ensembl ID		ENSG00000197774	ENSG00000187790
Uniprot IDs		A4GXA9	A0A8Q3WLG3 Q8IYD8
PDB IDs		7F6L	4BXO 4DAY 4DRB 4E45 4M6W
Enriched GO Terms of Interacting Partners?		FANCM-MHF Complex Fanconi Anaemia Nuclear Complex Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Interstrand Cross-link Repair Meiosis I Cell Cycle Process DNA Repair DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Nuclease Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process DNA Binding Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Damage Response Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Somite Specification Positive Regulation Of Protein Monoubiquitination Resolution Of Mitotic Recombination Intermediates Four-way Junction Helicase Activity Double-strand Break Repair Regulation Of Protein Monoubiquitination DNA Recombination Response To DNA Damage Checkpoint Signaling Chromatin Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Osteoblast Proliferation Double-strand Break Repair Via Break-induced Replication 3'-5' DNA Helicase Activity Protein Tag Activity Segment Specification Somite Development Four-way Junction DNA Binding Mitotic Intra-S DNA Damage Checkpoint Signaling Nuclear Replication Fork Cellular Response To Stress DNA Endonuclease Activity Nucleus Chromatin Binding DNA Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Replication Fork Homologous Recombination Nucleoplasm	Resolution Of DNA Recombination Intermediates Resolution Of Meiotic Recombination Intermediates RecQ Family Helicase-topoisomerase III Complex FANCM-MHF Complex Response To Stress Cellular Response To Manganese Ion Cellular Response To Stress DNA Repair Meiosis I Cell Cycle Process Fanconi Anaemia Nuclear Complex Response To Manganese Ion Golgi-associated Vesicle Reproductive Process Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity DNA Metabolic Process DNA Damage Response Presynaptic Cytosol Cellular Response To Metal Ion Regulation Of Neuron Differentiation Clathrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interstrand Cross-link Repair Replication Fork Processing Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Macromolecule Metabolic Process Double-strand Break Repair Regulation Of CAMP/PKA Signal Transduction DNA Recombination Modulation Of Excitatory Postsynaptic Potential Protein Sumoylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleoplasm Cytosol DNA Binding Endosome Acetylcholine Receptor Activator Activity Response To Metal Ion Positive Regulation Of Protein Metabolic Process
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