EME2

Description		essential meiotic structure-specific endonuclease subunit 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Nuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Enzyme-substrate Adaptor Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: FAAP24 FANCM MEOX2 MUS81 UBC
Entrez ID		197342
HPRD ID		16859
Ensembl ID		ENSG00000197774
Uniprot IDs		A4GXA9
PDB IDs		7F6L
Enriched GO Terms of Interacting Partners?		FANCM-MHF Complex Fanconi Anaemia Nuclear Complex Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Interstrand Cross-link Repair Meiosis I Cell Cycle Process DNA Repair DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Nuclease Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process DNA Binding Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Damage Response Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Somite Specification Positive Regulation Of Protein Monoubiquitination Resolution Of Mitotic Recombination Intermediates Four-way Junction Helicase Activity Double-strand Break Repair Regulation Of Protein Monoubiquitination DNA Recombination Response To DNA Damage Checkpoint Signaling Chromatin Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Osteoblast Proliferation Double-strand Break Repair Via Break-induced Replication 3'-5' DNA Helicase Activity Protein Tag Activity Segment Specification Somite Development Four-way Junction DNA Binding Mitotic Intra-S DNA Damage Checkpoint Signaling Nuclear Replication Fork Cellular Response To Stress DNA Endonuclease Activity Nucleus Chromatin Binding DNA Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Replication Fork Homologous Recombination Nucleoplasm
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