EME2 and MUS81

Number of citations of the paper that reports this interaction (PMID 17289582)
99

Data Source:
BioGRID (pull down)

		EME2	MUS81
Gene Name		essential meiotic structure-specific endonuclease subunit 2	MUS81 structure-specific endonuclease subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleolus
	Molecular Function	DNA Binding Endonuclease Activity	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	DNA Repair DNA Recombination Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Catabolic Process, Endonucleolytic DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		3 interactors: C19orf40 FANCM MUS81	5 interactors: CHEK2 EME1 EME2 SLX1A SLX4
Entrez ID		197342	80198
HPRD ID		16859	09419
Ensembl ID		ENSG00000197774	ENSG00000172732
Uniprot IDs		A4GXA9	Q53ES5 Q96NY9
PDB IDs			2MC3 2ZIX
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Chromosome Separation Response To Stress Reciprocal Meiotic Recombination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Meiotic Chromosome Segregation DNA Catabolic Process, Endonucleolytic Nitrogen Compound Metabolic Process Meiosis I DNA-dependent DNA Replication DNA Catabolic Process Meiotic Nuclear Division Cellular Response To Stimulus Meiotic Cell Cycle Chromosome Segregation	DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleic Acid Phosphodiester Bond Hydrolysis Response To Intra-S DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Double-strand Break Repair DNA Catabolic Process, Exonucleolytic Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Signal Transduction Involved In Intra-S DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Nuclear Cell Cycle DNA Replication Intra-S DNA Damage Checkpoint DNA Damage Induced Protein Phosphorylation Aromatic Compound Catabolic Process Replicative Senescence Catabolic Process Mitotic Spindle Assembly Response To Stimulus Mitotic Spindle Organization Response To Biotic Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Cell Aging Spindle Assembly Protein Stabilization Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint
Tagcloud ?			adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value
Tagcloud (Difference) ?			adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value
Tagcloud (Intersection) ?