EFNA5 and EPHA7

Number of citations of the paper that reports this interaction (PMID 10366629)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EFNA5	EPHA7
Gene Name		ephrin-A5	EPH receptor A7
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Chemorepellent Activity Ephrin Receptor Binding	Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Apoptotic Process Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Rac GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization	Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of ERK1 And ERK2 Cascade
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Hippocampal atrophy ( 19668339)	Dialysis-related mortality ( 21546767) Response to hepatitis C treatment ( 22095909)
Protein-Protein Interactions		10 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 GRIP1 SRC	8 interactors: EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MLLT4 ZNF267
Entrez ID		1946	2045
HPRD ID		03324	03721
Ensembl ID		ENSG00000184349	ENSG00000135333
Uniprot IDs		P52803	Q15375
PDB IDs		2X11 3MX0 4BK5 4BKA	2REI 3DKO 3H8M 3NRU
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Neuron Projection Development Neuron Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Peptidyl-amino Acid Modification Neurogenesis Cell Morphogenesis Cell Development Locomotion Protein Phosphorylation Nervous System Development Movement Of Cell Or Subcellular Component Response To External Stimulus Phosphorylation Cell Differentiation Anatomical Structure Morphogenesis System Development Regulation Of Intracellular Signal Transduction Retinal Ganglion Cell Axon Guidance Phosphate-containing Compound Metabolic Process Regulation Of MAPK Cascade Axonal Fasciculation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cellular Protein Modification Process Fasciculation Of Motor Neuron Axon Anatomical Structure Development Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Cell Migration Fasciculation Of Sensory Neuron Axon Developmental Process Cell Motility Signaling	Ephrin Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Communication Cell Projection Organization Locomotion Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Negative Regulation Of Dendritic Spine Morphogenesis Generation Of Neurons Positive Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Neurogenesis Anatomical Structure Development Cell Surface Receptor Signaling Pathway Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Mitral Valve Development Establishment Of Endothelial Intestinal Barrier Cardiac Muscle Cell Apoptotic Process Cell Differentiation Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Signaling Response To Stimulus Peptidyl-tyrosine Phosphorylation Notochord Morphogenesis
Tagcloud ?		adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive	aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique
Tagcloud (Difference) ?		adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive	aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique
Tagcloud (Intersection) ?