EIF2B5 and EIF2B4

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, biochemical)

		EIF2B5	EIF2B4
Gene Name		eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Ovarian Follicle Development Translation Translational Initiation Response To Heat Response To Glucose Gene Expression Astrocyte Development Oligodendrocyte Development Negative Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Cellular Response To Drug Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Astrocyte Differentiation	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Stimulus
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		11 interactors: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 EIF2B1 EIF2B2 EIF2B4 EIF2S2 GSK3A GSK3B	4 interactors: EIF2B2 EIF2B5 EIF2S1 EIF2S2
Entrez ID		8893	8890
HPRD ID		04898	09459
Ensembl ID		ENSG00000145191	ENSG00000115211
Uniprot IDs		Q13144	Q9UI10
PDB IDs		3JUI
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Response To Heat Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Oligodendrocyte Development Nervous System Development Hypermethylation Of CpG Island Negative Regulation Of Protein Metabolic Process Response To Temperature Stimulus Cellular Response To Interleukin-3 Neurogenesis Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Hydrolase Activity Translational Initiation Negative Regulation Of Glycogen (starch) Synthase Activity Cell Development Protein Metabolic Process Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translation In Response To Stress Oligodendrocyte Differentiation System Development Regulation Of Wnt Signaling Pathway Rhythmic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cellular Metabolic Process Protein Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Glial Cell Development Multicellular Organismal Development Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Mitotic Nuclear Division Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Translation In Response To Stress Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Anatomical Structure Development Regulation Of Mitotic Cell Cycle Response To Glucose Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Translational Initiation	Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Gonad Development Development Of Primary Sexual Characteristics Regulation Of Translation Sex Differentiation Oligodendrocyte Development Posttranscriptional Regulation Of Gene Expression Reproductive Structure Development Reproductive System Development Ovarian Follicle Development Oligodendrocyte Differentiation Ovulation Cycle Process Developmental Process Involved In Reproduction Glial Cell Development Female Gonad Development Response To Heat Ovulation Cycle Development Of Primary Female Sexual Characteristics Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Glucose Myelination Axon Ensheathment Response To Endoplasmic Reticulum Stress Positive Regulation Of Hydrolase Activity Reproduction Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Gene Expression Single Organism Reproductive Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gliogenesis Male Germ Cell Proliferation Reproductive Process Negative Regulation Of Translational Initiation In Response To Stress Rhythmic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Biosynthetic Process Response To Peptide Hormone Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Peptide
Tagcloud ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Difference) ?		1223t 3days 4months 584g antenatal cach cle cree exome hypomyelination i408t infantile lethargy patch poliovirus r195h resembling resides vomiting	1090c 1980s 314a 318a 877c atrophy compiled dystonic genetics hemiparesis hereditary list macrocephaly manifestation matter movements necropsy spain suffered
Tagcloud (Intersection) ?		ataxia deterioration leukoencephalopathy optic spasticity vanishing vwm