MEGF6 and CRKL

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		MEGF6	CRKL
Gene Name		multiple EGF-like-domains 6	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Region	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Biological_process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways			Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ATN1 ATXN7 CACNA1A CRKL EGFR GFI1B MFAP5	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		1953	1399
HPRD ID		11973	03596
Ensembl ID			ENSG00000099942
Uniprot IDs		O75095	P46109
PDB IDs			2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Vestibular Nucleus Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Transcription From RNA Polymerase II Promoter Activation Of Phospholipase A2 Activity Gamma-aminobutyric Acid Secretion Positive Regulation Of Phospholipase A2 Activity Regulation Of Acetylcholine Secretion, Neurotransmission Neurotrophin TRK Receptor Signaling Pathway Response To Cobalamin Response To UV-A Rhythmic Synaptic Transmission Negative Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Hydroxyisoflavone Central Nervous System Development Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Chloride Ion Homeostasis Calcium Ion-dependent Exocytosis Of Neurotransmitter System Development Activation Of Protein Kinase Activity Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Signal Transduction By Phosphorylation Positive Regulation Of Catenin Import Into Nucleus Parathyroid Gland Development Negative Regulation Of Hormone Biosynthetic Process Extracellular Fibril Organization Regulation Of Synaptic Transmission Regulation Of Phospholipase A2 Activity Pons Development Maintenance Of Cell Polarity Neurological System Process Regulation Of Superoxide Anion Generation Toxin Metabolic Process Sulfur Compound Metabolic Process Magnesium Ion Homeostasis Cerebellar Purkinje Cell Differentiation Multicellular Organismal Development Protein Localization To Membrane Regulation Of Phosphorylation Regulation Of Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?			actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?			actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?